Journal article
Multicenter clinical trials comparing cefotetan with moxalactam or cefoxitin as therapy for obstetric and gynecologic infections
The American journal of surgery, v 155(5), pp 56-60
1988
PMID: 3287970
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The clinical efficacy and safety of cefotetan was assessed in two multicenter clinical trials involving 335 evaluable patients hospitalized with obstetric and gynecologic infections. In Study I, cefotetan was compared with moxalactam and in Study II, cefotetan was compared with cefoxitin. The clinical response rate in Study I was 67 of 70 patients for cefotetan (96 percent) and 33 of 34 patients (97 percent) for moxalactam. In Study II, the clinical response rate was 138 of 147 patients in the cefotetan group (94 percent) and 76 of 84 patients in the cefoxitin group (91 percent). For the patients with bacteriologic response data, 196 of 205 cefotetan patients (96 percent), 23 of 24 moxalactam patients (96 percent), and 70 of 75 cefoxitin patients (93 percent) had a satisfactory bacteriologic response. Cefotetan was well tolerated and produced no major adverse reactions. The mean amout of cefotetan given was lower than that of moxalactam or cefoxitin.
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Details
- Title
- Multicenter clinical trials comparing cefotetan with moxalactam or cefoxitin as therapy for obstetric and gynecologic infections
- Creators
- Richard L. Sweet - University of California, San FranciscoStanley A. Gall - University of Illinois at ChicagoRonald S. Gibbs - The University of Texas at San AntonioDavid L. Hemsell - Dallas, Texas, USARobert A. Knuppel - University of TampaTimothy W. Lane - University of North Carolina at GreensboroR. David Miller - Orange (Belgium)Edward R. Newton - The University of Texas at San AntonioAlfred N. Poindexter - Houston, Texas, USAWilfred Reguero - Bronx, New York, USAMichael Spence - Philadelphia, Pennsylvania, USAStanley H. Tschler - Brooklyn, New York, USA
- Publication Details
- The American journal of surgery, v 155(5), pp 56-60
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Accelerated Career Entry Bachelor of Science in Nursing (BSN)
- Web of Science ID
- WOS:A1988N718300011
- Scopus ID
- 2-s2.0-0023894506
- Other Identifier
- 991019184315704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Surgery