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Multidimensional brain-age prediction reveals altered brain developmental trajectory in psychiatric disorders
Journal article   Open access   Peer reviewed

Multidimensional brain-age prediction reveals altered brain developmental trajectory in psychiatric disorders

Xin Niu, Alexei Taylor, Russell T Shinohara, John Kounios and Fengqing Zhang
Cerebral cortex (New York, N.Y. 1991), v 32(22), pp 5036-5049
09 Nov 2022
DOI: https://doi.org/10.1093/cercor/bhab530
PMID: 35094075
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1101/2020.12.24.424350View
SubmittedOpen Access (License Unspecified),  Open

Abstract

Brain - diagnostic imaging Brain - pathology Humans Machine Learning Magnetic Resonance Imaging - methods Mental Disorders - diagnostic imaging Mental Disorders - pathology
Brain-age prediction has emerged as a novel approach for studying brain development. However, brain regions change in different ways and at different rates. Unitary brain-age indices represent developmental status averaged across the whole brain and therefore do not capture the divergent developmental trajectories of various brain structures. This staggered developmental unfolding, determined by genetics and postnatal experience, is implicated in the progression of psychiatric and neurological disorders. We propose a multidimensional brain-age index (MBAI) that provides regional age predictions. Using a database of 556 individuals, we identified clusters of imaging features with distinct developmental trajectories and built machine learning models to obtain brain-age predictions from each of the clusters. Our results show that the MBAI provides a flexible analysis of region-specific brain-age changes that are invisible to unidimensional brain-age. Importantly, brain-ages computed from region-specific feature clusters contain complementary information and demonstrate differential ability to distinguish disorder groups (e.g., depression and oppositional defiant disorder) from healthy controls. In summary, we show that MBAI is sensitive to alterations in brain structures and captures distinct regional change patterns that may serve as biomarkers that contribute to our understanding of healthy and pathological brain development and the characterization and diagnosis of psychiatric disorders.

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12 Record Views
10 citations in Web of Science
12 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Neurosciences
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