Journal article
Multifunctional Mesoporous Silica Nanoprobes: Material Chemistry-Based Fabrication and Bio-Imaging
Advanced therapeutics, v 1(8)
01 Dec 2018
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Nanoparticles-based bioimaging probes are attracting broad attention for various biomedical applications. As one of the mostly explored nanoplatforms, mesoporous silica nanoparticles (MSNs) show high clinical-translation potential for diagnostic probing/imaging. Based on their tunable morphology, abundant surface chemistry, and well-defined mesostructure, MSNs are regarded as the desirable platforms for constructing diverse nanoprobes via incorporation of a variety of functional moieties or components. In this review, the authors summarize and discuss recent progress in the rational design and fabrication of multifunctional mesoporous silica-based composite nanoprobes for versatile bioimaging applications. Four kinds of methodologies for the fabrication of these mesoporous silica-based nanoprobes are discussed, including encapsulating functional nanoparticles within a mesoporous silica shell, assembling functional nanoparticles on the surface of MSNs, dispersing nanoparticles into the nanometer-scale mesopores of MSNs, and doping functional moieties into the framework of MSNs. The applications of mesoporous silica nanoprobes in magnetic resonance imaging, ultrasound imaging, computed tomography imaging, fluorescence imaging, positron emission computed tomography, photoacoustic (PA) imaging, and even multimodality imaging are discussed in detail. The biosafety of MSN-based composite nanoplatforms as bioimaging nanoprobes is also highlighted, accompanied by a deep discussion on facing the challenges and future developments for guaranteeing their further potential clinical translation.
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Details
- Title
- Multifunctional Mesoporous Silica Nanoprobes: Material Chemistry-Based Fabrication and Bio-Imaging
- Creators
- Luodan Yu - University of Chinese Academy of SciencesHan Lin - Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R ChinaXiangyu Lu - University of Chinese Academy of SciencesYu Chen - Shanghai Institute of Ceramics
- Publication Details
- Advanced therapeutics, v 1(8)
- Publisher
- Wiley
- Number of pages
- 20
- Grant note
- 51722211; 51672303 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) 2015QNRC001 / Young Elite Scientist Sponsorship Program by CAST 2016YFA0203700 / National Key R&D Program of China 18XD1404300 / Program of Shanghai Academic Research Leader
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000506348700005
- Scopus ID
- 2-s2.0-85071169107
- Other Identifier
- 991019186980704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pharmacology & Pharmacy