Journal article
Multimodality multidimensional image analysis of cortical and subcortical plasticity in the rat brain
Annals of biomedical engineering, v 24(3), pp 430-439
01 Jan 1996
PMID: 8734064
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In this work, we developed and implemented a multimodality multidimensional imaging system which is capable of generating and displaying anatomical and functional images of selected structures and processes within a vertebrate's central nervous system (CNS). The functional images are generated from [ super(14)C]-2-deoxy-D-glucose (2DG) autoradiography whereas the anatomic images are derived from cytochrome oxidase (CO) histochemistry. This multi-modality imaging system has been used to study mechanisms underlying information processing in the rat brain. We have applied this technique to visualize and measure the plasticity (deformation) observed in the rat's whisker system due to neonatal lesioning-of selected peripheral sensory organs. Application of this imaging system revealed detailed information about the shape, size, and directionality of selected cortical and subcortical structures. Previous 2-D imaging techniques were unable to deliver such holistic information. Another important issue addressed in this work is related to image registration problems. We developed an image registration technique which employs extrinsic fiduciary marks for alignment and is capable of registering images with subpixel accuracy. It uses the information from all available fiduciary marks to promote alignment of the sections and to avoid propagation of errors across a serial data set.
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Details
- Title
- Multimodality multidimensional image analysis of cortical and subcortical plasticity in the rat brain
- Creators
- Alberto Goldszal - Drexel UniversityOleh Tretiak - Drexel UniversityDemeral Liu - Institute of ImmunologyPeter Hand - University of Pennsylvania
- Publication Details
- Annals of biomedical engineering, v 24(3), pp 430-439
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1996UK31800012
- Scopus ID
- 2-s2.0-0030152698
- Other Identifier
- 991019167744904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical