Journal article
Multinozzle deposition for construction of 3D biopolymer tissue scaffolds
Rapid prototyping journal, v 11(1)
01 Feb 2005
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose To introduce recent research and development of biopolymer deposition for freeform fabrication of threedimensional tissue scaffolds that is capable of depositing bioactive ingredients. Designmethodologyapproach A multinozzle biopolymer deposition system is developed, which is capable of extruding biopolymer solutions and living cells for freeform construction of 3D tissue scaffolds. The deposition process is biocompatible and occurs at room temperature and low pressures to reduce damage to cells. In contrast with other systems, this system is capable of, simultaneously with scaffold construction, depositing controlled amount of cells, growth factors, or other bioactive compounds with precise spatial position to form complex cellseeded tissue constructs. The examples shown are based on sodium alginate solutions and polycaprolactone PCL. Studies of the biopolymer deposition feasibility, structural formability, and different material deposition through a multinozzle heterogeneous system are conducted and presented. Findings Provides information about the biopolymer deposition using different nozzle systems, the relations of process parameters on deposition flow rate and scaffold structural formability. Threedimensional alginatebased scaffolds and scaffold embedded with living cells can be freeform constructed according to various design configurations at room temperature without using toxic materials. Research limitationsimplications Other biopolymers may also be studied for structure formation. Studying cell viability and cellular tissue engineering behavior of the scaffolds after the cell deposition should be further investigated. Practical implications A very useful and effective tool for construction of bioactive scaffolds for tissue engineering applications based on a multinozzle biopolymer deposition. Originalityvalue This paper describes a novel process and manufacturing system for fabrication of bioactive tissue scaffolds, automatic cell loading, and heterogeneous tissue constructs for emerging regenerative medicine.
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Details
- Title
- Multinozzle deposition for construction of 3D biopolymer tissue scaffolds
- Creators
- S. Khalil - Drexel UniversityJ. Nam - Drexel UniversityW. Sun - Drexel University
- Publication Details
- Rapid prototyping journal, v 11(1)
- Publisher
- Emerald Group Publishing Limited
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000227133000003
- Scopus ID
- 2-s2.0-13844256142
- Other Identifier
- 991019167650504721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Mechanical
- Materials Science, Multidisciplinary