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Journal article
Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models
Frontiers in behavioral neuroscience, v 10, pp 136-136
30 Jun 2016
PMID: 27445731
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Fragile X is the most common monogenic disorder associated with intellectual disability (ID) and autism spectrum disorders (ASD). Additionally, many patients are afflicted with executive dysfunction, ADHD, seizure disorder and sleep disturbances. Fragile X is caused by loss of FMRP expression, which is encoded by the
FMR1
gene. Both the fly and mouse models of fragile X are also based on having no functional protein expression of their respective
FMR1
homologs. The fly model displays well defined cognitive impairments and structural brain defects and the mouse model, although having subtle behavioral defects, has robust electrophysiological phenotypes and provides a tool to do extensive biochemical analysis of select brain regions. Decreased cAMP signaling has been observed in samples from the fly and mouse models of fragile X as well as in samples derived from human patients. Indeed, we have previously demonstrated that strategies that increase cAMP signaling can rescue short term memory in the fly model and restore DHPG induced mGluR mediated long term depression (LTD) in the hippocampus to proper levels in the mouse model (McBride et al.,
2005
; Choi et al.,
2011
,
2015
). Here, we demonstrate that the same three strategies used previously with the potential to be used clinically, lithium treatment, PDE-4 inhibitor treatment or mGluR antagonist treatment can rescue long term memory in the fly model and alter the cAMP signaling pathway in the hippocampus of the mouse model.
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Details
- Title
- Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models
- Creators
- Catherine H. Choi - Drexel UniversityBrian P. Schoenfeld - University of PennsylvaniaAaron J. Bell - University of PennsylvaniaJoseph Hinchey - Albert Einstein College of MedicineCory Rosenfelt - University of AlbertaMichael J. Gertner - Albert Einstein College of MedicineSean R. Campbell - Albert Einstein College of MedicineDanielle Emerson - University of PennsylvaniaPaul Hinchey - Albert Einstein College of MedicineMaria Kollaros - Albert Einstein College of MedicineNeal J. Ferrick - University of PennsylvaniaDaniel B. Chambers - University of AlbertaSteven Langer - University of AlbertaSteven Sust - University of PennsylvaniaAatika Malik - University of PennsylvaniaAllison M. Terlizzi - Albert Einstein College of MedicineDavid A. Liebelt - Albert Einstein College of MedicineDavid Ferreiro - Albert Einstein College of MedicineAli Sharma - Albert Einstein College of MedicineEric Koenigsberg - Albert Einstein College of MedicineRichard J. Choi - Albert Einstein College of MedicineNatalia Louneva - University of PennsylvaniaSteven E. Arnold - University of PennsylvaniaRobert E. Featherstone - University of PennsylvaniaSteven J. Siegel - University of PennsylvaniaR. Suzanne Zukin - Albert Einstein College of MedicineThomas V. McDonald - Albert Einstein College of MedicineFrancois V. Bolduc - University of AlbertaThomas A. Jongens - University of PennsylvaniaSean M. J. McBride - Albert Einstein College of MedicineArchana Malik - Pediatrics
- Publication Details
- Frontiers in behavioral neuroscience, v 10, pp 136-136
- Publisher
- Frontiers Media S.A
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000378896600001
- Scopus ID
- 2-s2.0-84978958238
- Other Identifier
- 991019173713304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Behavioral Sciences
- Neurosciences