Journal article
Multiple Rhythm-Generating Circuits Act in Tandem with Pacemaker Properties to Control the Start and Speed of Locomotion
Neuron (Cambridge, Mass.), v 105(6), pp 1048-1061.e4
18 Mar 2020
PMID: 31982322
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In vertebrates, specific command centers in the brain can selectively drive slow-explorative or fast-speed locomotion. However, it remains unclear how the locomotor central pattern generator (CPG) processes descending drive into coordinated locomotion. Here, we reveal, in adult zebrafish, a logic of the V2a interneuron rhythm-generating circuits involving recurrent and hierarchical connectivity that acts in tandem with pacemaker properties to provide an ignition and gear-shift mechanism to start locomotion and change speed. A comprehensive mapping of synaptic connections reveals three recurrent circuit modules engaged sequentially to increase locomotor speed. The connectivity between V2a interneurons of different modules displayed a clear asymmetry in favor of connections from faster to slower modules. The interplay between V2a interneuron pacemaker properties and their organized connectivity provides a mechanism for locomotor initiation and speed control. Thus, our results provide mechanistic insights into how the spinal CPG transforms descending drive into locomotion and align its speed with the initial intention.
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Details
- Title
- Multiple Rhythm-Generating Circuits Act in Tandem with Pacemaker Properties to Control the Start and Speed of Locomotion
- Creators
- Jianren Song - Tongji UniversityIrene Pallucchi - Karolinska InstituteJessica Ausborn - Drexel UniversityKonstantinos Ampatzis - Karolinska InstituteMaria Bertuzzi - Karolinska InstitutePierre Fontanel - Karolinska InstituteLaurence D. Picton - Karolinska InstituteAbdeljabbar El Manira - Karolinska Institute
- Publication Details
- Neuron (Cambridge, Mass.), v 105(6), pp 1048-1061.e4
- Publisher
- Elsevier
- Number of pages
- 18
- Grant note
- KAW 2018.0010 / Knut and Alice Wallenberg Foundation, Sweden; Knut & Alice Wallenberg Foundation FO2018-0306 / Swedish Brain Foundation, Sweden 2017-02905 / Swedish Research Council, Sweden; Swedish Research Council Karolinska Institutet, Sweden; Karolinska Institutet
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000520854700013
- Scopus ID
- 2-s2.0-85081290127
- Other Identifier
- 991019168256404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences