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Journal article
Multiple mechanisms of 3D migration: the origins of plasticity
Current opinion in cell biology, v 42, pp 7-12
Oct 2016
PMID: 27082869
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cells migrate through 3D environments using a surprisingly wide variety of molecular mechanisms. These distinct modes of migration often rely on the same intracellular components, which are used in different ways to achieve cell motility. Recent work reveals that how a cell moves can be dictated by the relative amounts of cell-matrix adhesion and actomyosin contractility. A current concept is that the level of difficulty in squeezing the nucleus through a confining 3D environment determines the amounts of adhesion and contractility required for cell motility. Ultimately, determining how the nucleus controls the mode of cell migration will be essential for understanding both physiological and pathological processes dependent on cell migration in the body.
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Details
- Title
- Multiple mechanisms of 3D migration: the origins of plasticity
- Creators
- Ryan J Petrie - Drexel UniversityKenneth M Yamada - National Institute of Dental and Craniofacial Research
- Publication Details
- Current opinion in cell biology, v 42, pp 7-12
- Publisher
- Elsevier
- Grant note
- ZIA DE000524-25 / Intramural NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000386363300003
- Scopus ID
- 2-s2.0-84962860386
- Other Identifier
- 991019167907404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology