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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Multiple myeloma and family history of lymphohaematopoietic cancers: Results from the International Multiple Myeloma Consortium
British journal of haematology, v 175(1)
01 Oct 2016
PMID: 27330041
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Family clusters of multiple myeloma (MM) suggest disease heritability. Nevertheless, patterns of inheritance and the importance of genetic versus environmental risk factors in MM aetiology remain unclear. We pooled data from eleven case-control studies from the International Multiple Myeloma Consortium to characterize the association of MM risk with having a first-degree relative with a history of a lympho-haematapoietic cancer. Unconditional logistic regression models, adjusted for study, sex, age and education level, were used to estimate associations between MM risk and having a first-degree relative with a history of non-Hodgkin lymphoma, Hodgkin lymphoma, leukaemia or MM. Sex, African American race/ethnicity and age were explored as effect modifiers. A total of 2843 cases and 11470 controls were included. MM risk was elevated in association with having a first-degree relative with any lympho-haematapoietic cancer (Odds Ratio (OR)=129, 95% Confidence Interval (CI): 108-155). The association was particularly strong for having a first-degree relative with MM (OR=190, 95% CI: 126-287), especially among men (OR=413, 95% CI: 217-785) and African Americans (OR=552, 95% CI: 187-1627).These results support the hypothesis that genetic inheritance plays a role in MM aetiology. Future studies are warranted to characterize interactions of genetic markers with environmental exposures.
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Details
- Title
- Multiple myeloma and family history of lymphohaematopoietic cancers: Results from the International Multiple Myeloma Consortium
- Creators
- Leah H. Schinasi - Drexel UniversityElizabeth E. Brown - University of Alabama at BirminghamNicola J. Camp - University of UtahSophia S. Wang - Beckman Research InstituteJonathan N. Hofmann - National Cancer InstituteBrian C. Chiu - Chicago Department of Public HealthLucia Miligi - Institute for Study and Prevention of Cancer Unit of Environmental and Occupational Health Florence ItalyLaura E. Beane Freeman - National Cancer InstituteSilvia de Sanjose - Cancer Epidemiology Research Programme Catalan Institute of Oncology Barcelona SpainLeslie Bernstein - Beckman Research InstituteAlain Monnereau - SorbonneJacqueline Clavel - SorbonneGuido J. Tricot - University of IowaDjordje Atanackovic - University of UtahPierluigi Cocco - University of CagliariLaurent Orsi - SorbonneJames A. Dosman - University of SaskatchewanJohn R. McLaughlin - Public Health OntarioMark P. Purdue - National Cancer InstituteWendy Cozen - University of Southern CaliforniaJohn J. Spinelli - BC Cancer AgencyAnneclaire J. de Roos - Drexel University
- Publication Details
- British journal of haematology, v 175(1)
- Publisher
- Wiley
- Number of pages
- 15
- Grant note
- Intramural Research Program of the NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA U54CA118948; R21CA155951; R25CA76023; R01CA186646 / NCI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R21ES021592 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) P30CA13148 / NCI (University of Alabama at Birmingham Comprehensive Cancer Center Support grant) AFSSET Association pour la Recherche contre le Cancer; Fondation ARC pour la Recherche sur le Cancer R21 ES021592 / National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) IRG60-001-47 / American Cancer Society Fondation de France R01CA186646 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000384808300012
- Scopus ID
- 2-s2.0-84988515957
- Other Identifier
- 991019168264404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Hematology