Journal article
Multiple myeloma and occupation: A pooled analysis by the International Multiple Myeloma Consortium
Cancer epidemiology, v 37(3), pp 300-305
Jun 2013
PMID: 23403129
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: We investigated occupational risk of multiple myeloma (MM) in a pooled analysis of five international case–control studies. Methods: We calculated the odds ratio and its 95% confidence interval for selected occupations with unconditional regression analysis in 1959 MM cases and 6192 controls, by pooling study-specific risks using random-effects meta-analysis. Exposure to organic solvents was assessed with a job-exposure matrix (JEM). Results: Gardeners and nursery workers combined, most likely exposed to pesticides, showed a 50% increase in risk (OR=1.50, 95% CI 0.9–2.3), while other farming jobs did not. Metal processors (OR=1.55, 95% CI 0.9–2.3), female cleaners (OR=1.32, 95% CI 1.0–1.8), and high level exposure to organic solvents (OR=1.38, 95% CI 0.96–1.8) also showed moderately increased risks. Conclusions: Additional case–control studies of MM aetiology are warranted to further investigate the nature of the repeatedly reported increase in MM risk in several occupational groups.
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Details
- Title
- Multiple myeloma and occupation: A pooled analysis by the International Multiple Myeloma Consortium
- Creators
- Carla Perrotta - Hospital Italiano de Buenos AiresSilke Kleefeld - Ollscoil na Gaillimhe – University of GalwayAnthony Staines - Dublin City UniversityPrerna Tewari - Trinity College DublinAnneclaire J. De Roos - Fred Hutchinson Cancer Research CenterDalsu Baris - National Cancer InstituteBrenda Birmann - Brigham and Women's HospitalBrian Chiu - University of ChicagoWendy Cozen - University of Southern CaliforniaNikolaus Becker - German Cancer Research CenterLenka Foretova - Department of Cancer Epidemiology and Genetics, Brno, Czech RepublicMarc Maynadié - Dijon University Hospital, Dijon, FranceAlexandra Nieters - University of FreiburgSilvia de Sanjosé - Centro de Investigación Biomédica en Red de Epidemiología y Salud PúblicaLucia Miligi - Florence (Netherlands)Adele Seniori Costantini - Florence (Netherlands)Mark Purdue - National Cancer InstituteJohn Spinelli - BC Cancer AgencyPierluigi Cocco - University of Cagliari
- Publication Details
- Cancer epidemiology, v 37(3), pp 300-305
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000318677600015
- Scopus ID
- 2-s2.0-84876307008
- Other Identifier
- 991020099699304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology
- Public, Environmental & Occupational Health