Journal article
Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus
Nature genetics, v 40(9), pp 1062-1064
01 Sep 2008
PMID: 19165919
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The TNFAIP3 (tumor necrosis factor alpha-induced protein 3) gene encodes a ubiquitin editing enzyme, A20, that restricts NF-kappa B-dependent signaling and prevents inflammation. We show that three independent SNPs in the TNFAIP3 region (rs13192841, rs2230926 and rs6922466) are associated with systemic lupus erythematosus (SLE) among individuals of European ancestry. These findings provide critical links between A20 and the etiology of SLE.
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Details
- Title
- Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus
- Creators
- Stacy L. Musone - University of California, San FranciscoKimberly E. Taylor - University of California, San FranciscoTimothy T. Lu - University of California, San FranciscoJoanne Nititham - University of California, San FranciscoRicardo C. Ferreira - GenentechWard Ortmann - GenentechNataliya Shifrin - University of California, San FranciscoMichelle A. Petri - Johns Hopkins MedicineM. Ilyas Kamboh - University of PittsburghSusan Manzi - University of PittsburghMichael F. Seldin - University of California, DavisPeter K. Gregersen - Northwell HealthTimothy W. Behrens - GenentechAveril Ma - University of California, San FranciscoPui-Yan Kwok - Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USALindsey A. Criswell - University of California, San Francisco
- Publication Details
- Nature genetics, v 40(9), pp 1062-1064
- Publisher
- Springer Nature
- Number of pages
- 3
- Grant note
- 5 M01 RR-00079 / National Center for Research Resources; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) NO1-AR-1-2256 / ABCoN contract M01RR000079 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) R01HL074165 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) N01AI095386 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) K24AR002175 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) Rainin Foundation Mary Kirkland Center for Lupus Research T32DK007007 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) US Public Health Service; United States Department of Health & Human Services; United States Public Health Service
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000258761200017
- Scopus ID
- 2-s2.0-50449103533
- Other Identifier
- 991021934008904721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Genetics & Heredity