Journal article
Multiple renin forms in the adrenal gland
American journal of physiology: endocrinology and metabolism, v 255(4), pp E531-E536
01 Oct 1988
PMID: 3052104
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Abstract
Renin heterogeneity has been described in rat kidney and plasma. In this study, we used the isoelectric focusing method to 1) characterize the adrenal renin forms in control rats, in rats on low- and high-Na diets, and in nephrectomized rats; and 2) examine their resemblance with plasma renin. Active renin (AR) and inactive trypsin-activatable renin (IR) were measured in adrenal homogenates and plasma. Aliquots were subjected to isoelectric focusing gels. Activation with trypsin (5 mg/ml) was performed before or after isoelectric focusing. Results showed that adrenal glands contained AR and IR. The content of adrenal AR increased significantly only in rats fed a low-Na diet. Following anesthesia, nephrectomy, or high-Na intake, the content of adrenal AR and IR was not significantly changed. In plasma, an inverse relationship between AR and IR was found. Adrenal glands contained six forms of AR focusing at the same pH as those of plasma AR but in different proportions. After activation of IR in adrenal glands, two additional renin forms focusing at pH 6.4 and 6.1 were found, whereas after activation of plasma IR, two peaks focusing at pH 5.9 and 4.8 were significantly enhanced. Adrenal AR forms were modified by alterations of salt and water balance differently than plasma AR. These results support the hypotheses of an endogenous production of renin forms by the adrenal gland.
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Details
- Title
- Multiple renin forms in the adrenal gland
- Creators
- S. H Kim - Department of Physiology, University of Michigan, Ann Arbor48109F. M Sessler - Department of Physiology, University of Michigan, Ann Arbor48109R. L Malvin - Department of Physiology, University of Michigan, Ann Arbor48109
- Publication Details
- American journal of physiology: endocrinology and metabolism, v 255(4), pp E531-E536
- Publisher
- American Physiological Society (APS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1988Q370200040
- Scopus ID
- 2-s2.0-0023801871
- Other Identifier
- 991014878106404721
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- Web of Science research areas
- Physiology