Journal article
Multivalent dendrimeric compounds containing carbohydrates expressed on immune cells inhibit infection by primary isolates of HIV-1
Virology (New York, N.Y.), v 408(1)
2010
PMID: 20880566
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Specific glycosphingolipids (GSL), found on the surface of target immune cells, are recognized as alternate cell surface receptors by the human immunodeficiency virus type 1 (HIV-1) external envelope glycoprotein. In this study, the globotriose and 3'-sialyllactose carbohydrate head groups found on two GSL were covalently attached to a dendrimer core to produce two types of unique multivalent carbohydrates (MVC). These MVC inhibited HIV-1 infection of T cell lines and primary peripheral blood mononuclear cells (PBMC) by T cell line-adapted viruses or primary isolates, with IC
50s ranging from 0.1 to 7.4
μg/ml. Inhibition of Env-mediated membrane fusion by MVC was also observed using a dye-transfer assay. These carbohydrate compounds warrant further investigation as a potential new class of HIV-1 entry inhibitors. The data presented also shed light on the role of carbohydrate moieties in HIV-1 virus–host cell interactions.
►Multivalent carbohydrates (MVCs) inhibited infection of PBMCs by HIV-1. ►MVCs inhibited infection by T cell line-adapted viruses. ►MVCs inhibited infection by primary isolates of HIV-1. ►MVCs inhibited Env-mediated membrane fusion.
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Details
- Title
- Multivalent dendrimeric compounds containing carbohydrates expressed on immune cells inhibit infection by primary isolates of HIV-1
- Creators
- Andrew Rosa Borges - Military HIV Research Program, Henry M. Jackson Foundation, Rockville, MD 20850, USALindsay Wieczorek - Military HIV Research Program, Henry M. Jackson Foundation, Rockville, MD 20850, USABenitra Johnson - Center for Cancer Research, National Cancer Institute, NIH, Frederick, MD, USAAlan J Benesi - Department of Chemistry, The Pennsylvania State University, State College, PA, USABruce K Brown - Military HIV Research Program, Henry M. Jackson Foundation, Rockville, MD 20850, USARichard D Kensinger - Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA, USAFred C Krebs - Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USABrian Wigdahl - Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USARobert Blumenthal - Center for Cancer Research, National Cancer Institute, NIH, Frederick, MD, USAAnu Puri - Center for Cancer Research, National Cancer Institute, NIH, Frederick, MD, USAFrancine E McCutchan - Military HIV Research Program, Henry M. Jackson Foundation, Rockville, MD 20850, USADeborah L Birx - Military HIV Research Program, Division of Retrovirology, Walter Reed Army Institute of Research, Rockville, MD, USAVictoria R Polonis - Military HIV Research Program, Division of Retrovirology, Walter Reed Army Institute of Research, Rockville, MD, USACara-Lynne Schengrund - Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA, USA
- Publication Details
- Virology (New York, N.Y.), v 408(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000283970500009
- Scopus ID
- 2-s2.0-78049264354
- Other Identifier
- 991014877984204721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Virology