Journal article
Murine Coronavirus-Induced Hepatitis: JHM Genetic Background Eliminates A59 Spike-Determined Hepatotropism
Journal of virology, v 77(8), pp 4972-4978
Apr 2003
PMID: 12663803
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recombinant murine coronaviruses, differing only in the spike gene and containing the strain A59 (moderately hepatotropic) and JHM (neurotropic) spike genes in the background of the JHM genome, were compared for the ability to replicate in the liver and induce hepatitis in weanling C57BL/6 mice. Interestingly, expression of the A59 spike glycoprotein within the background of the neurotropic JHM strain does not reproduce the A59 hepatotropic phenotype. Thus, the JHM genetic background plays a dominant role over the spike in the determination of hepatotropism.
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Details
- Title
- Murine Coronavirus-Induced Hepatitis: JHM Genetic Background Eliminates A59 Spike-Determined Hepatotropism
- Creators
- Sonia Navas - Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6076Susan R Weiss - Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6076
- Publication Details
- Journal of virology, v 77(8), pp 4972-4978
- Publisher
- American Society for Microbiology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000181970200050
- Scopus ID
- 2-s2.0-0037384952
- Other Identifier
- 991014877691704721
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- Web of Science research areas
- Virology