Journal article
Murine Coronavirus Spike Protein Determines the Ability of the Virus To Replicate in the Liver and Cause Hepatitis
Journal of virology, v 75(5), pp 2452-2457
Mar 2001
PMID: 11160748
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recombinant mouse hepatitis viruses (MHV) differing only in the spike gene, containing A59, MHV-4, and MHV-2 spike genes in the background of the A59 genome, were compared for their ability to replicate in the liver and induce hepatitis in weanling C57BL/6 mice infected with 500 PFU of each virus by intrahepatic injection. Penn98-1, expressing the MHV-2 spike gene, replicated to high titer in the liver, similar to MHV-2, and induced severe hepatitis with extensive hepatocellular necrosis. S
A59
R13, expressing the A59 spike gene, replicated to a somewhat lower titer and induced moderate to severe hepatitis with zonal necrosis, similar to MHV-A59. S
4
R21, expressing the MHV-4 spike gene, replicated to a minimal extent and induced few if any pathological changes, similar to MHV-4. Thus, the extent of replication and the degree of hepatitis in the liver induced by these recombinant viruses were determined largely by the spike protein.
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Details
- Title
- Murine Coronavirus Spike Protein Determines the Ability of the Virus To Replicate in the Liver and Cause Hepatitis
- Creators
- Sonia Navas - Departments of MicrobiologySu-Hun Seo - Departments of MicrobiologyMing Ming Chua - Departments of MicrobiologyJayasri Das Sarma - Departments of MicrobiologyEhud Lavi - Departments of MicrobiologySusan T Hingley - Departments of MicrobiologySusan R Weiss - Departments of Microbiology
- Publication Details
- Journal of virology, v 75(5), pp 2452-2457
- Series
- Note
- Publisher
- American Society for Microbiology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000166881000042
- Scopus ID
- 2-s2.0-0035127581
- Other Identifier
- 991014878226804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Virology