Journal article
Mussel-Inspired Naturally Derived Double-Network Hydrogels and Their Application in 3D Printing: From Soft, Injectable Bioadhesives to Mechanically Strong Hydrogels
ACS biomaterials science & engineering, v 6(3), pp 1798-1808
09 Mar 2020
PMID: 33455396
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
As promising candidates for tissue engineering, hydrogels possess great potential, especially in bioadhesives and load-bearing tissue scaffolds. However, a strategy for synthesizing hydrogels that could achieve the above requirements remains a challenge. Here, a mussel-inspired naturally derived double-network (DN) hydrogel composed of a special combination of two well-characterized natural polymers, hyaluronic acid and alginate, is presented. The key features are its two-step synthesis strategy, which generates injectable and adhesive properties in the first step and then transforms into a DN hydrogel with high mechanical strength and good resilient properties. Based on this strategy, the DN hydrogel could be tamed into a self-supporting three-dimensional (3D) printable bioink. As a rheological modifier, alginate was used to lubricate the covalent cross-linking hydrogels for better extrusion performance. The incorporation of alginate also enhanced the mechanical performance of the soft covalent network by forming reversible alginate–Ca2+ ionic cross-links, which interpenetrate through the outer water-retention scaffold with delicate weblike structures. In vitro cell culture data indicated that our bioink formulation and printing strategy are compatible with human umbilical vein endothelial cells (HUVECs).
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Details
- Title
- Mussel-Inspired Naturally Derived Double-Network Hydrogels and Their Application in 3D Printing: From Soft, Injectable Bioadhesives to Mechanically Strong Hydrogels
- Creators
- Zhongwei Guo - Tsinghua–Berkeley Shenzhen InstituteJingjing Xia - Tsinghua UniversityShengli Mi - Tsinghua UniversityWei Sun - Tsinghua–Berkeley Shenzhen Institute
- Publication Details
- ACS biomaterials science & engineering, v 6(3), pp 1798-1808
- Publisher
- American Chemical Society; Washington, DC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000519150300046
- Scopus ID
- 2-s2.0-85080961037
- Other Identifier
- 991019167437304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Materials Science, Biomaterials