Journal article
Mutations in apoptotic genes and micronucleus occurrence in vinyl chloride-exposed workers in China
Environmental and molecular mutagenesis, v 58(1)
Jan 2017
PMID: 27801956
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Vinyl chloride is an occupational carcinogen which caused micronuclei in human directly. It has recently been demonstrated that micronuclei formation could generate a spectrum of genomic rearrangements and play a key role in the early tumorigenesis process. We aimed to investigate the association between polymorphisms in the apoptosis process related genes and micronuclei rate in vinyl chloride-exposed workers in China.
Cytokinesis block micronucleus test was performed on 342 vinyl chloride-exposed workers and 107 nonexposed workers to determine chromosomal damage. The polymerase chain reaction and restriction fragment length polymorphism technique were used to detect nine Single Nucleotide Polymorphisms in the apoptosis process related genes.
There was a highly significant dose-response relationship between vinyl chloride exposure and chromosomal damage. Individuals carrying the variant heterozygote MDM2 -309T > G (rs2279744) and variant homozygote BCL2 -938C > A (rs2279115) were at higher risk for chromosomal damage compared with their wild-type genotype, respectively. Although individuals possessing the variant genotype of BAX -248G > A (rs4645878) had decreased risk compared with the corresponding wild type, this did not reach statistical significant.
Genetic polymorphisms in genes related to apoptosis process may have an impact on chromosomal damage induced by vinyl chloride. Environ. Mol. Mutagen. 58:39-45, 2017. © 2016 Wiley Periodicals, Inc.
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Details
- Title
- Mutations in apoptotic genes and micronucleus occurrence in vinyl chloride-exposed workers in China
- Creators
- Nannan Feng - Fudan University, and Key laboratory of public health and safety of Ministry of Education of China Department of Occupational Health and Toxicology, School of Public Health Shanghai ChinaGuoqiao Zheng - Department of Occupational Health and Toxicology, School of Public Health, Fudan University, and Key laboratory of public health and safety of Ministry of Education of China, Shanghai, 200032, ChinaYanhui Hao - Department of Occupational Health and Toxicology, School of Public Health, Fudan University, and Key laboratory of public health and safety of Ministry of Education of China, Shanghai, 200032, ChinaYong Li - Fudan University, and Key laboratory of public health and safety of Ministry of Education of China Department of Occupational Health and Toxicology, School of Public Health Shanghai ChinaYandan Xu - Fudan University, and Key laboratory of public health and safety of Ministry of Education of China Department of Occupational Health and Toxicology, School of Public Health Shanghai ChinaXiaowen Xu - Department of Occupational Health and Toxicology, School of Public Health, Fudan University, and Key laboratory of public health and safety of Ministry of Education of China, Shanghai, 200032, ChinaGuanghui Zhang - Department of Occupational Health and Toxicology, School of Public Health, Fudan University, and Key laboratory of public health and safety of Ministry of Education of China, Shanghai, 200032, ChinaJinwei Wang - Fudan University, and Key laboratory of public health and safety of Ministry of Education of China Department of Occupational Health and Toxicology, School of Public Health Shanghai ChinaYongliang Li - University of Illinois at ChicagoPaul Brandt-Rauf - University of Illinois ChicagoZhao-Lin Xia - Fudan University, and Key laboratory of public health and safety of Ministry of Education of China Department of Occupational Health and Toxicology, School of Public Health Shanghai China
- Publication Details
- Environmental and molecular mutagenesis, v 58(1)
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000394680800004
- Scopus ID
- 2-s2.0-85010645166
- Other Identifier
- 991019176804204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Genetics & Heredity
- Toxicology