Journal article
Myenteric ganglionic 5-hydroxytryptamine(1P) signal transmission is mediated via Go protein
The Journal of pharmacology and experimental therapeutics, v 277(1), pp 518-524
01 Apr 1996
PMID: 8613962
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The role of G proteins in mediating the signal transduction of the guinea pig myenteric ganglionic 5-hydroxytryptamine (5-HT)1P receptors was examined. Stimulation of ganglionic membranes with 5-HT in the presence of [35S]GTPgammaS or [alpha 32P]GTP increased guanine nucleotide binding to G(alpha)o but not to G(alpha)s, G(alpha)i or G(alpha)q in a concentration-dependent fashion. Pertussis toxin pretreatment markedly reduce this 5-HT induced response. Similarly, the 5-HT1P receptor-mediated slowly developing and long-lasting depolarizing response is potentiated by GTPgammaS and is inhibited by GDPbetaS or pertussis toxin. The activation of G(alpha)o by 5-HT also was mimicked by the 5-HT1P agonist, 5-hydroxyindalpine and was blocked by the selective 5-HT1P antagonist, N-acetyl-5-hydroxytryptophyl-5-hydroxytryptophan amide. These data provide compelling evidence to suggest that transmembrane signaling for the 5-HT1P receptors in isolated myenteric ganglia is transduced by the trimeric Go protein.
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Details
- Title
- Myenteric ganglionic 5-hydroxytryptamine(1P) signal transmission is mediated via Go protein
- Creators
- H Y WangE Fiorica-HowellsH PanM D GershonE Friedman
- Publication Details
- The Journal of pharmacology and experimental therapeutics, v 277(1), pp 518-524
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1996UE58500065
- Scopus ID
- 2-s2.0-0030437249
- Other Identifier
- 991019168413704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy