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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Myomatrix arrays for high-definition muscle recording
bioRxiv : the preprint server for biology
22 Feb 2023
PMID: 36865176
Abstract
Neurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding of motor control has grown rapidly thanks to new methods for recording and analyzing populations of many individual neurons over time. In contrast, current methods for recording the nervous system's actual motor output - the activation of muscle fibers by motor neurons - typically cannot detect the individual electrical events produced by muscle fibers during natural behaviors and scale poorly across species and muscle groups. Here we present a novel class of electrode devices ("Myomatrix arrays") that record muscle activity at cellular resolution across muscles and behaviors. High-density, flexible electrode arrays allow for stable recordings from the muscle fibers activated by a single motor neuron, called a "motor unit", during natural behaviors in many species, including mice, rats, primates, songbirds, frogs, and insects. This technology therefore allows the nervous system's motor output to be monitored in unprecedented detail during complex behaviors across species and muscle morphologies. We anticipate that this technology will allow rapid advances in understanding the neural control of behavior and in identifying pathologies of the motor system.
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Details
- Title
- Myomatrix arrays for high-definition muscle recording
- Creators
- Bryce ChungMuneeb ZiaKyle ThomasJonathan A MichaelsAmanda JacobAndrea PackMatt WilliamsKailash NagapudiLay Heng TengEduardo ArrambideLogan OuelletteNicole OeyRhuna GibbsPhilip AnschutzJiaao LuYu WuMehrdad KashefiTomomichi OyaRhonda KerstenAlice MosbergerSean O'ConnellRunming WangHugo MarquesAna Rita MendesConstanze LenschowGayathri KondakathJeong Jun KimWilliam OlsonKiara QuinnPierce PerkinsGraziana GattoAyesha ThanawallaSusan ColtmanTaegyo KimTrevor SmithBen Binder-MarkeyMartin ZabackChristopher K ThompsonSimon GiszterAbigail PersonMartyn GouldingEiman AzimNitish ThakorDaniel O'ConnorBarry TrimmerSusana Q LimaMegan CareyChethan PandarinathRui M CostaJ Andrew PruszynskiMuhannad BakirSamuel J Sober
- Publication Details
- bioRxiv : the preprint server for biology
- Publisher
- American Physical Society (APS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; College of Medicine; Drexel University; Physical Therapy (and Rehabilitation Sciences)
- Other Identifier
- 991020186993104721