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Journal article
Myomatrix arrays for high-definition muscle recording
ELIFE, v 12, RP88551
19 Dec 2023
PMID: 38113081
Abstract
Neurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding of motor control has grown rapidly thanks to new methods for recording and analyzing populations of many individual neurons over time. In contrast, current methods for recording the nervous system's actual motor output - the activation of muscle fibers by motor neurons - typically cannot detect the individual electrical events produced by muscle fibers during natural behaviors and scale poorly across species and muscle groups. Here we present a novel class of electrode devices ('Myomatrix arrays') that record muscle activity at unprecedented resolution across muscles and behaviors. High-density, flexible electrode arrays allow for stable recordings from the muscle fibers activated by a single motor neuron, called a 'motor unit,' during natural behaviors in many species, including mice, rats, primates, songbirds, frogs, and insects. This technology therefore allows the nervous system's motor output to be monitored in unprecedented detail during complex behaviors across species and muscle morphologies. We anticipate that this technology will allow rapid advances in understanding the neural control of behavior and identifying pathologies of the motor system.
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Details
- Title
- Myomatrix arrays for high-definition muscle recording
- Publication Details
- ELIFE, v 12, RP88551
- Publisher
- eLIFE SCIENCES PUBL LTD; CAMBRIDGE
- Grant note
- National Institute of Neurological Disorders and Stroke RF1NS128898 Eiman AzimNational Institute of Neurological Disorders and Stroke U19NS112959 Eiman AzimNational Institute of Neurological Disorders and Stroke U24NS126936 Bryce Chung Muneeb Zia Jonathan A Michaels Amanda Jacob Andrea Pack Matthew J Williams Kailash Nagapudi Lay Heng Teng Eduardo Arrambide Logan Ouellette Nicole Oey Rhuna Gibbs Philip Anschutz Jiaao Lu Yu Wu Muhannad Bakir Samuel J SoberNational Institute of Neurological Disorders and Stroke F31NS124347 Simon Giszter Taegyo KimNational Institute of Neurological Disorders and Stroke R01NS111643 Graziana Gatto Martyn GouldingSwiss National Science Foundation P2EZP3_172128 Alice C MosbergerNational Institutes of Health DP2NS127291 Chethan Pandarinath National Science Foundation DGE-1937971 Kyle A ThomasNational Science Foundation DGE-1444932 Andrea Pack The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:001128090800001
- Other Identifier
- 991021860717504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biology