Files and links (1)
Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Myopia Stabilization and Associated Factors Among Participants in the Correction of Myopia Evaluation Trial (COMET)
Investigative ophthalmology & visual science, v 54(13), pp 7871-7883
03 Dec 2013
PMID: 24159085
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
PURPOSE. To use the Gompertz function to estimate the age and the amount of myopia at stabilization and to evaluate associated factors in the Correction of Myopia Evaluation Trial (COMET) cohort, a large ethnically diverse group of myopic children.
METHODS. The COMET enrolled 469 ethnically diverse children aged 6 to younger than 12 years with spherical equivalent refraction between -1.25 and -4.50 diopters (D). Noncycloplegic refraction was measured semiannually for 4 years and annually thereafter. Right eye data were fit to individual Gompertz functions in participants with at least 6 years of follow-up and at least seven refraction measurements over 11 years. Function parameters were estimated using a nonlinear least squares procedure. Associated factors were evaluated using linear regression.
RESULTS. In total, 426 participants (91%) had valid Gompertz curve fits. The mean (SD) age at myopia stabilization was 15.61 (4.17) years, and the mean (SD) amount of myopia at stabilization was -4.87 (2.01) D. Ethnicity (P < 0.0001) but not sex or the number of myopic parents was associated with the age at stabilization. Ethnicity (P = 0.02) and the number of myopic parents (P = 0.01) but not sex were associated with myopia magnitude at stabilization. At stabilization, African Americans were youngest (mean age, 13.82 years) and had the least myopia (mean, -4.36 D). Participants with two versus no myopic parents had approximately 1.00 D more myopia at stabilization. The age and the amount of myopia at stabilization were correlated (r = -0.60, P < 0.0001).
CONCLUSIONS. The Gompertz function provides estimates of the age and the amount of myopia at stabilization in an ethnically diverse cohort. These findings should provide guidance on the time course of myopia and on decisions regarding the type and timing of interventions.
Metrics
Details
- Title
- Myopia Stabilization and Associated Factors Among Participants in the Correction of Myopia Evaluation Trial (COMET)
- Creators
- Li Ming Dong - College Station Medical CenterMelissa Fazzari - College Station Medical CenterJane Gwiazda - College Station Medical CenterLeslie Hyman - College Station Medical CenterThomas Norton - College Station Medical CenterFrank Thorn - College Station Medical CenterQinghua Zhang - College Station Medical CenterCOMET Study GrpMitchell Scheiman - Pennsylvania College of Optometry (PCO)
- Publication Details
- Investigative ophthalmology & visual science, v 54(13), pp 7871-7883
- Publisher
- Assoc Research Vision Ophthalmology Inc
- Number of pages
- 13
- Grant note
- EY11756; EY11754; EY11805; EY11752; EY11740; EY11755 / National Eye Institute/National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) U10EY011752 / NATIONAL EYE INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000328133800006
- Scopus ID
- 2-s2.0-84889677202
- Other Identifier
- 991021900614404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Ophthalmology