Journal article
Myricetin attenuates hypoxia-induced inflammation in human adipocytes
MOLECULAR BIOLOGY REPORTS, v 50(12), p9833
Dec 2023
PMID: 37843712
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background:Adipose tissue hypoxia plays a crucial role in the development of chronic low-grade systemic inflammation which has been associated with the pathogenesis of obesity-related diseases. Myricetin is a natural compound present in numerous plant-based foods with presumed anti-inflammatory and beneficial health effects. The impact of this flavonoid on hypoxia-induced expression of inflammatory adipokines and hypoxia-regulated pathways is unknown so far and has been addressed in the present study. Methods:Differentiated human Simpson-Golabi-Behmel syndrome (SGBS) adipocytes were cultured with or without myricetin under normoxic and hypoxic conditions for varying time periods. The effect of hypoxia and myricetin on the expression of the investigated adipokines was measured by real-time RT-PCR. Western blot analysis was used for the detection of transcription factors involved in hypoxia-regulated pathways. Results:Myricetin interfered in the hypoxia-induced regulation of adipokines and the underlying pathways, which are involved in transmitting the inflammatory response. It strongly repressed hypoxia-induced expression of apelin, leptin, chemerin, asprosin, and DPP-4 and HIF-1 alpha accumulation in the nucleus was diminished. Furthermore, the activation of the key regulators in the inflammatory response NF-kappa B, Akt, and CREB was suppressed by myricetin under hypoxic conditions. Myricetin also decreased hypoxia-induced accumulation of the pro-tumorigenic transcription factors Snail and Slug in the nucleus. Conclusion:Taken together, our results indicated that myricetin regulated hypoxia-induced expression of adipokines and hypoxia-regulated pathways in human adipocytes. Our study therefore provided evidence of the anti-inflammatory effects of myricetin in hypoxia-treated human adipocytes.
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Details
- Title
- Myricetin attenuates hypoxia-induced inflammation in human adipocytes
- Publication Details
- MOLECULAR BIOLOGY REPORTS, v 50(12), p9833
- Publisher
- SPRINGER; DORDRECHT
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:001084635900002
- Scopus ID
- 2-s2.0-85174256141
- Other Identifier
- 991021861182704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology