Journal article
N-Alkyldeoxynojirimycin derivatives with novel terminal tertiary amide substitution for treatment of bovine viral diarrhea virus (BVDV), Dengue, and Tacaribe virus infections
Bioorganic & medicinal chemistry letters, v 23(7), pp 2172-2176
01 Apr 2013
PMID: 23453839
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Novel N-alkyldeoxynojirimycins (NADNJs) with two hydrophobic groups attached to a nitrogen linker on the alkyl chain were designed. A novel NADNJ containing a terminal tertiary carboxamide moiety was discovered that was a potent inhibitor against BVDV. Further optimization resulted in a structurally more stable lead compound 24 with a submicromolar EC50 against BVDV, Dengue, and Tacaribe; and low cytotoxicity.
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Details
- Title
- N-Alkyldeoxynojirimycin derivatives with novel terminal tertiary amide substitution for treatment of bovine viral diarrhea virus (BVDV), Dengue, and Tacaribe virus infections
- Creators
- Yanming Du - Baruch S. Blumberg InstituteHong Ye - Hepatitis B FoundationTina Gill - Drexel UniversityLijuan Wang - Drexel UniversityFang Guo - Drexel UniversityAndrea Cuconati - Hepatitis B FoundationJu-Tao Guo - Drexel UniversityTimothy M Block - Drexel UniversityJinhong Chang - Drexel UniversityXiaodong Xu - Hepatitis B Foundation
- Publication Details
- Bioorganic & medicinal chemistry letters, v 23(7), pp 2172-2176
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000316642900052
- Scopus ID
- 2-s2.0-84875220428
- Other Identifier
- 991019167518304721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic