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N-Terminal Pro-B-Type Natriuretic Peptide and Longitudinal Risk of Hypertension
Journal article   Open access   Peer reviewed

N-Terminal Pro-B-Type Natriuretic Peptide and Longitudinal Risk of Hypertension

Charles D Nicoli, Timothy B Plante, D Leann Long, Suzanne E Judd, Leslie A McClure, Pankaj Arora and Mary Cushman
American journal of hypertension, v 34(5), pp 476-483
22 May 2021
DOI: https://doi.org/10.1093/ajh/hpaa224
PMID: 33378421
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1093/ajh/hpaa224View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Blacks - statistics & numerical data Female Heart Disease Risk Factors Humans Hypertension - epidemiology Hypertension - ethnology Longitudinal Studies Male Middle Aged Natriuretic Peptide, Brain - blood Peptide Fragments - blood United States - epidemiology Whites - statistics & numerical data
Hypertension is a common condition that increases risk for future cardiovascular disease. N-terminal B-type natriuretic peptide (NT-proBNP) is higher in individuals with hypertension, but studies of its association with hypertension risk have been mixed. The REasons for Geographic And Racial Differences in Stroke (REGARDS) study enrolled 30,239 U.S. Black or White adults aged ≥45 years from 2003 to 2007. A subcohort included 4,400 participants who completed a second assessment in 2013-2016. NT-proBNP was measured by immunoassay in 1,323 participants without baseline hypertension, defined as blood pressure ≥140/90 or self-reported antihypertensive prescriptions. Two robust Poisson regression models assessed hypertension risk, yielding incidence rate ratios (IRRs): Model 1 included behavioral and demographic covariates and Model 2 added risk factors. A sensitivity analysis using a less conservative definition of hypertension (blood pressure ≥130/80 or self-reported antihypertensive prescriptions) was conducted. Four hundred and sixty-six participants developed hypertension after mean follow-up of 9.4 years. NT-proBNP was not associated with hypertension (Model 2 IRR per SD log NT-proBNP 1.01, 95% confidence interval 0.92-1.12), with no differences by sex, body mass index, age, or race. Similar findings were seen in lower-threshold sensitivity analysis. NT-proBNP was not associated with incident hypertension in REGARDS; this did not differ by race or sex.

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6 citations in Web of Science
6 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Peripheral Vascular Disease
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