Files and links (1)
SubmittedOpen Access (License Unspecified), Open
Journal article
N-Terminal Pro-B-Type Natriuretic Peptide and Risk of Future Cognitive Impairment in the REGARDS Cohort
Journal of Alzheimer's disease, v 54(2), pp 497-503
01 Jan 2016
PMID: 27567834
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Improved understanding of the etiology of cognitive impairment is needed to develop effective preventive interventions. Higher amino-terminal pro-B-type natriuretic peptide (NT-proBNP) is a biomarker of cardiac dysfunction associated with risk cardiovascular diseases and stroke in apparently healthy people.
Objective: To study the association of NT-proBNP with risk of incident cognitive impairment.
Methods: The Reasons for Geographic and Racial Differences in Stroke is a national cohort study of 30,239 black and white Americans age 45 and older at baseline, enrolled in 2003-7. Among participants without prebaseline stroke or cognitive impairment, baseline NT-proBNP was measured in 470 cases of incident cognitive impairment and 557 controls. Cases were participants scoring below the 6th percentile of demographically-adjusted means on at least 2 of 3 serially administered tests (word list learning, word list recall and semantic fluency) over 3.5 years follow-up.
Results: Adjusting for age, gender, race, region of residence, education, and income, there was an increased odds ratio of incident cognitive impairment with increasing NT-proBNP; participants in the 4th versus 1st quartile (>127 versus <= 33 pg/ml) had a 1.69-fold increased odds (95% CI 1.11-2.58). Adjustment for cardiovascular risk factors and presence of an apolipoprotein E4 allele had no substantial impact on the odds ratio. Results did not differ by age, race, gender, or presence of an apolipoprotein E4 allele.
Conclusion: Higher NT-pro-BNP was associated with incident cognitive impairment in this prospective study, independent of atherogenic and Alzheimer's disease risk factors. Future work should clarify pathophysiologic connections of NT-proBNP and cognitive dysfunction.
Metrics
Details
- Title
- N-Terminal Pro-B-Type Natriuretic Peptide and Risk of Future Cognitive Impairment in the REGARDS Cohort
- Creators
- Mary Cushman - University of VermontPeter W. Callas - University of VermontLeslie A. McClure - Drexel UniversityFrederick W. Unverzagt - Indiana UniversityVirginia J. Howard - University of Alabama at BirminghamSarah R. Gillett - University of VermontEvan L. Thacker - Brigham Young UniversityVirginia G. Wadley - University of Alabama at Birmingham
- Publication Details
- Journal of Alzheimer's disease, v 54(2), pp 497-503
- Publisher
- Ios Press
- Number of pages
- 7
- Grant note
- U01 NS041588 / National Institute of Neurological Disorders and Stroke (NINDS) National Institutes of Health (NIH), Department of Health and Human Service U01NS041588 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000384087200007
- Scopus ID
- 2-s2.0-84986616781
- Other Identifier
- 991019168964304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences