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Accepted (AM)Open Access (License Unspecified), Open
Journal article
N-acetylcysteine yields sex-specific efficacy for cue-induced reinstatement of nicotine seeking
Addiction biology, v 25(1), e12711
Jan 2020
PMID: 30734439
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Women report greater craving during certain phases of the menstrual cycle. As well, research indicates that pharmacotherapies for smoking may be less efficacious in women compared with men, which may be due to interactions with natural fluctuations in ovarian hormone levels. N-Acetylcysteine (NAC) is a glutamatergic compound that has shown some efficacy in treating substance use disorders and aids in the prevention of relapse. However, it is unclear whether NAC has sex-specific effectiveness for nicotine relapse treatment. Given that NAC has shown promise to reduce nicotine reinstatement in preclinical models using male rats, the exploration of potential sex differences in the efficacy of NAC is warranted. Using a rat model, we first investigated the ability of NAC treatment (100 mg/kg, ip) during nicotine withdrawal with extinction training to reduce cue-induced nicotine seeking in male and female rats. Next, we assessed whether NAC's effects were estrous cycle-dependent for female rats. Results show that following NAC treatment during extinction, reinstatement of nicotine seeking was significantly decreased in males but not females, indicating a sex-specific effect of NAC. Furthermore, for females, both vehicle- and NAC-treated groups significantly reinstated nicotine-seeking behavior compared with extinction, regardless of estrous cycle phase. These results suggest that NAC is inefficacious in reducing nicotine relapse in females regardless of estrous cycle phase at the dose evaluated here. These collective findings could have important clinical implications for use and efficacy of NAC as a pharmacotherapy for freely cycling women smokers.
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Details
- Title
- N-acetylcysteine yields sex-specific efficacy for cue-induced reinstatement of nicotine seeking
- Creators
- Julianna Goenaga - Arizona State UniversityGregory L Powell - Arizona State UniversityJonna M Leyrer-Jackson - Arizona State UniversityJose Piña - Arizona State UniversitySandy Phan - Arizona State UniversityAlesia V Prakapenka - Arizona State UniversityStephanie V Koebele - Arizona State UniversityMark D Namba - Arizona State UniversityErin A McClure - Medical University of South CarolinaHeather A Bimonte-Nelson - Arizona State UniversityCassandra D Gipson - Arizona State University
- Publication Details
- Addiction biology, v 25(1), e12711
- Publisher
- Wiley
- Grant note
- K99 DA036569 / NIDA NIH HHS R01 AG028084 / NIA NIH HHS P30 AG019610 / NIA NIH HHS R21 DA044479 / NIDA NIH HHS R00 DA036569 / NIDA NIH HHS R03 DA045881 / NIDA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000571503200016
- Scopus ID
- 2-s2.0-85061255956
- Other Identifier
- 991021955155804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Substance Abuse