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NBC: the Naïve Bayes Classification tool webserver for taxonomic classification of metagenomic reads
Journal article   Open access   Peer reviewed

NBC: the Naïve Bayes Classification tool webserver for taxonomic classification of metagenomic reads

Gail L Rosen, Erin R Reichenberger and Aaron M Rosenfeld
Bioinformatics (Oxford, England), v 27(1), pp 127-129
01 Jan 2011
PMID: 21062764
url
https://doi.org/10.1093/bioinformatics/btq619View
Published, Version of Record (VoR) Open

Abstract

Applications Note
Motivation: Datasets from high-throughput sequencing technologies have yielded a vast amount of data about organisms in environmental samples. Yet, it is still a challenge to assess the exact organism content in these samples because the task of taxonomic classification is too computationally complex to annotate all reads in a dataset. An easy-to-use webserver is needed to process these reads. While many methods exist, only a few are publicly available on webservers, and out of those, most do not annotate all reads. Results: We introduce a webserver that implements the naïve Bayes classifier (NBC) to classify all metagenomic reads to their best taxonomic match. Results indicate that NBC can assign next-generation sequencing reads to their taxonomic classification and can find significant populations of genera that other classifiers may miss. Availability: Publicly available at: http://nbc.ece.drexel.edu . Contact: gailr@ece.drexel.edu

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181 citations in Scopus

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Web of Science research areas
Biochemical Research Methods
Biotechnology & Applied Microbiology
Computer Science, Interdisciplinary Applications
Mathematical & Computational Biology
Statistics & Probability
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