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Journal article
NH2-Terminal Pro-Brain Natriuretic Peptide and Risk of Diabetes
Diabetes (New York, N.Y.), v 62(9), pp 3189-3193
01 Sep 2013
PMID: 23733199
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Brain natriuretic peptide (BNP) has an established role in cardiovascular disease (CVD). However, recent animal studies suggest direct metabolic effects of BNP. To determine the association of BNP with the risk of diabetes, we conducted a prospective analysis of participants from the Atherosclerosis Risk in Communities (ARIC) study. We included 7,822 men and women without history of diabetes, CVD, or reduced kidney function at baseline. At baseline, NH...-terminal (NT)-proBNP, a cleavage product of BNP, was inversely associated with adiposity, fasting glucose, insulin, and cholesterol but positively associated with blood pressure and C-reactive protein levels. During a median follow-up of 12 years, 1,740 participants reported a new diagnosis of diabetes or medication use for diabetes. Baseline quartiles of NT-proBNP were inversely associated with diabetes risk, even after multivariable adjustment including fasting glucose. The adjusted HRs for diabetes were 1.0 (reference), 0.84 (95% CI 0.74-0.96), 0.79 (95% CI 0.68-0.90), and 0.75 (95% CI 0.64-0.87) for the 1st, 2nd, 3rd, and 4th quartiles of baseline NT-proBNP, respectively (P for trend <0.001). This inverse association was robust across sex, race, and obesity subgroups. Our results extend animal studies and support a direct and important metabolic role of BNP in humans. (ProQuest: ... denotes formulae/symbols omitted.)
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Details
- Title
- NH2-Terminal Pro-Brain Natriuretic Peptide and Risk of Diabetes
- Creators
- Mariana LazoJ YoungFrederick BrancatiJosef CoreshSeamus WheltonChiadi NdumeleRon HoogeveenChristie BallantyneElizabeth Selvin
- Publication Details
- Diabetes (New York, N.Y.), v 62(9), pp 3189-3193
- Publisher
- American Diabetes Association
- Number of pages
- 5
- Grant note
- Roche Diagnostics National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P30DK079637 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) HHSN268201100005C; HHSN268201100006C; HHSN268201100007C; HHSN268-201100008C; HHSN268201100009C; HHSN2682011000-10C; HHSN268201100011C; HHSN268201100012C / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000323421000026
- Scopus ID
- 2-s2.0-84887363815
- Other Identifier
- 991020550340704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism