Journal article
NMDA Receptors in Dopaminergic Neurons Are Crucial for Habit Learning
Neuron (Cambridge, Mass.), v 72(6), pp 1055-1066
22 Dec 2011
PMID: 22196339
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Dopamine is crucial for habit learning. Activities of midbrain dopaminergic neurons are regulated by the cortical and subcortical signals among which glutamatergic afferents provide excitatory inputs. Cognitive implications of glutamatergic afferents in regulating and engaging dopamine signals during habit learning, however, remain unclear. Here, we show that mice with dopaminergic neuron-specific NMDAR1 deletion are impaired in a variety of habit-learning tasks, while normal in some other dopamine-modulated functions such as locomotor activities, goal-directed learning, and spatial reference memories. In vivo neural recording revealed that dopaminergic neurons in these mutant mice could still develop the cue-reward association responses; however, their conditioned response robustness was drastically blunted. Our results suggest that integration of glutamatergic inputs to DA neurons by NMDA receptors, likely by regulating associative activity patterns, is a crucial part of the cellular mechanism underpinning habit learning.
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Details
- Title
- NMDA Receptors in Dopaminergic Neurons Are Crucial for Habit Learning
- Creators
- Lei Phillip Wang - Augusta UniversityFei Li - Augusta UniversityDong Wang - Augusta UniversityKun Xie - Augusta UniversityDeheng Wang - Augusta UniversityXiaoming Shen - Shanghai Jiao Tong UniversityJoe Z. Tsien - Augusta University
- Publication Details
- Neuron (Cambridge, Mass.), v 72(6), pp 1055-1066
- Publisher
- Elsevier
- Number of pages
- 12
- Grant note
- R01NS079774 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) NIA; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R01AG034663 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) NIMH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01MH060236 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) Georgia Research Alliance
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000298771000018
- Scopus ID
- 2-s2.0-84155183278
- Other Identifier
- 991020643815704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences