Journal article
NOP2/Sun RNA methyltransferase 2 promotes tumor progression via its interacting partner RPL6 in gallbladder carcinoma
Cancer science, v 110(11), pp 3510-3519
Nov 2019
PMID: 31487418
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
NOP2/Sun domain family, member 2 (NSUN2) is a nuclear RNA methyl-transferase catalyzing 5-methylcytosine formation. Evidence shows that NSUN2 is correlated with cell unlimited proliferation. However, its functional role in gallbladder carcinoma (GBC), which is the most common biliary tract malignancy and has a poor prognosis, remains to be determined. Here we found that NSUN2 was highly expressed in GBC tissues as well as cell lines. NSUN2 silencing repressed GBC cell proliferation and tumorigenesis both in vitro and in vivo. Conversely, upregulation of NSUN2 enhanced GBC cell growth and colony formation. We further discovered that RPL6 was a closely interacting partner with NSUN2. Silencing RPL6 resulted in insufficient NSUN2 translational level and accumulative NSUN2 transcriptional level. Exogenous expression of NSUN2 partially rescued the effect of RPL6 in gallbladder cancer progression. Taken together, our data provided novel mechanic insights into the function of NSUN2 in GBC, thus pointing to NSUN2 as a potential and effective therapeutic approach to GBC treatment.
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Details
- Title
- NOP2/Sun RNA methyltransferase 2 promotes tumor progression via its interacting partner RPL6 in gallbladder carcinoma
- Creators
- Yuan Gao - XinHua HospitalZheng Wang - XinHua HospitalYidi Zhu - XinHua HospitalQin Zhu - XinHua HospitalYang Yang - XinHua HospitalYunpeng Jin - XinHua HospitalFei Zhang - XinHua HospitalLin Jiang - XinHua HospitalYuanyuan Ye - XinHua HospitalHuaifeng Li - XinHua HospitalYichi Zhang - XinHua HospitalHaibin Liang - XinHua HospitalShanshan Xiang - XinHua HospitalHuijie Miao - XinHua HospitalYingbin Liu - XinHua HospitalYajuan Hao - XinHua HospitalHualou Liang - School of Biomedical Engineering, Science, and Health Systems (1997-)
- Publication Details
- Cancer science, v 110(11), pp 3510-3519
- Publisher
- Wiley
- Grant note
- 17DZ2260200 / Shanghai Key Laboratory of Biliary Tract Disease Research Foundation 31620103910 / National Natural Science Foundation of China 2018BSH02 / Postdoctoral Initial Foundation of Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine 2017M61025 / China Postdoctoral Science Foundation 19QA14 05900 / Shanghai Science and Technology Committee Rising-Star Program 2017ZZ02011 / General Surgery Construction Program of Shanghai Municipal Health Commission 31701124 / National Natural Science Foundation of China SHDC12018107 / Emerging Frontier Program of Hospital Development Center 81874181 / National Natural Science Foundation of China 91440203 / National Natural Science Foundation of China
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000499928800011
- Scopus ID
- 2-s2.0-85073812804
- Other Identifier
- 991019320614104721
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- Oncology