Journal article
NY-BR-1 and PAX8 Immunoreactivity in Breast, Gynecologic Tract, and Other CK7+ Carcinomas Potential Use for Determining Site of Origin
American journal of clinical pathology, v 136(3), pp 428-435
01 Sep 2011
PMID: 21846919
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The distinction between breast and mullerian carcinomas from each other and from tumors with a similar cytokeratin profile can be difficult. We tested the usefulness of 2 new markers, NY-BR-1 and PAX8, by staining a variety of breast and gynecologic carcinomas, along with tumors of pancreas, bile ducts, stomach, and gastroesophageal junction. NY-BR-1 expression (ie, H score > 10) was seen in 58.4% of breast carcinomas (111/190), 5.6% of mullerian carcinomas (8/142), 7% of pancreatic tumors (1/15), 0% of cholangiocarcinomas (0/22), 0% of gastric tumors (0/36), and 0% of gastroesophageal carcinomas (0/25). All 188 breast carcinomas were negative for PAX8. PAX8 expression was seen in 72.4% of mullerian tumors (105/145). All pancreatic tumors (n = 15), cholangiocarcinomas (n = 23), and gastric (n = 35) and gastroesophageal junction (n = 25) carcinomas were negative for PAX8. Addition of NY-BR-1 and PAX8 in a panel would be useful in distinguishing breast cancer, gynecologic tumors, and tumors of the upper gastrointestinal tract.
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Details
- Title
- NY-BR-1 and PAX8 Immunoreactivity in Breast, Gynecologic Tract, and Other CK7+ Carcinomas Potential Use for Determining Site of Origin
- Creators
- Anna H. Woodard - Magee-Womens HospitalJing Yu - Magee-Womens HospitalDavid J. Dabbs - Magee-Womens HospitalSushil Beriwal - Magee-Womens HospitalAnca V. Florea - Magee-Womens HospitalEsther Elishaev - Magee-Womens HospitalJon M. Davison - UPMC PresbyterianAlyssa M. Krasinskas - UPMC PresbyterianRohit Bhargava - Magee-Womens Hospital
- Publication Details
- American journal of clinical pathology, v 136(3), pp 428-435
- Publisher
- Oxford Univ Press
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000294075800012
- Scopus ID
- 2-s2.0-80052678083
- Other Identifier
- 991021897265804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pathology