Journal article
Na +,K+-ATPase Activity and Subunit Isoform Protein Abundance: Effects of Antenatal Glucocorticoids in the Frontal Cerebral Cortex and Renal Cortex of Ovine Fetuses
Reproductive sciences (Thousand Oaks, Calif.), v 16(3), 294
01 Mar 2009
PMID: 19001554
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We examined the effects of single and multiple maternal glucocorticoid courses on cerebral cortical (CC) and renal cortical (RC) Na+,K+-ATPase activity and protein isoform abundance in fetal sheep. Ewes received four dexamethasone or placebo injections in the single course (SC) groups, and the same treatment once a week for five-weeks in the multiple course (MC) groups. CC Na +,K+-ATPase a2-abundance was higher (P<0.05) and β2-abundance lower in the SC dexamethasone than placebo group, but Na+,K+-ATPase activity did not change. CC Na+,K+-ATPase activity, a1-, β1 -, and β2-abundance were lower in the MC dexamethasone than placebo group, but a2- and a3-abundance did not change. Both dexamethasone courses did not affect CC cell number. RC Na +,K+-ATPase activity, a1- and β1 -abundance were higher in the MC dexamethasone than placebo group, but did not change in the SC dexamethasone group. We conclude MC, but not a SC of dexamethasone, affect fetal cerebral and renal Na+,K+-ATPase, and MC result in differential effects on Na+,K+-ATPase in these organs.
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Details
- Title
- Na +,K+-ATPase Activity and Subunit Isoform Protein Abundance: Effects of Antenatal Glucocorticoids in the Frontal Cerebral Cortex and Renal Cortex of Ovine Fetuses
- Creators
- Najma S. Mehter - The Ohio State UniversityGrazyna B. Sadowska - Brown UniversityShadi N. Malaeb - Women & Infants Hospital of Rhode IslandBarbara S. Stonestreet - Brown University
- Publication Details
- Reproductive sciences (Thousand Oaks, Calif.), v 16(3), 294
- Publisher
- SAGE Publications
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000263386600010
- Scopus ID
- 2-s2.0-60049084222
- Other Identifier
- 991021838279004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Reproductive Biology