Journal article
NaF-PET/CT global assessment in detecting and quantifying subclinical cardiac atherosclerosis and its association with blood pressure in non-dyslipidemic individuals
American journal of cardiovascular disease, v 10(2), pp 101-107
01 Jan 2020
PMID: 32685267
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: We used F-18-sodium fluoride (NaF) to assess early atherosclerosis in the global heart in asymptomatic individuals with a coronary calcium score of zero and without a formal diagnosis of hypertension. We hypothesized that these individuals might present with subclinical atherosclerosis that correlates with systolic, diastolic and mean arterial pressure (SBP, DBP, and MAP). Methods: We identified 20 asymptomatic individuals (41.6 +/- 13.8 years, 8 females) from the CAMONA trial with C-reactive protein >= 3 mg/L, no smoking history, diabetes (fasting blood glucose <126 mg/dl) and dyslipidemia per the Adult Treatment Panel Ill Guidelines: untreated LDL <160 mg/dL, total cholesterol <240 mg/dL, HDL >40 mg/dL. All underwent PET/CT imaging 90 minutes after NaF injection (2.2 Mbq/Kg). The global cardiac average SUVmean (aSUVmean) was calculated for each individual. Correlation coefficients and linear regression models were employed for statistical analysis. Results: Significant positive correlation was revealed between global cardiac NaF uptake and all blood pressures: SBP (r=0.44, P=0.05), DBP (r=0.64, P=0.002), and MAP (r=0.59, P=0.007). After adjusting for age and gender, DBP and MAP were independent predictors of higher global cardiac NaF uptake. Conclusion: NaF PET/CT for detecting and quantifying subclinical atherosclerosis in asymptomatic individuals revealed that cardiac NaF uptake correlated independently with DBP and MAP.
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Details
- Title
- NaF-PET/CT global assessment in detecting and quantifying subclinical cardiac atherosclerosis and its association with blood pressure in non-dyslipidemic individuals
- Creators
- Chaitanya Rojulpote - Univ Penn, Dept Radiol, 34-00 Spruce St, Philadelphia, PA 19104 USAShivaraj Patil - Univ Penn, Dept Radiol, 34-00 Spruce St, Philadelphia, PA 19104 USAKarthik Gonuguntla - Univ Penn, Dept Radiol, 34-00 Spruce St, Philadelphia, PA 19104 USAPranav Karamelkar - College Station Medical CenterPaco E. Bravos - Univ Penn, Dept Radiol, 34-00 Spruce St, Philadelphia, PA 19104 USASiavash M. Seraj - Univ Penn, Dept Radiol, 34-00 Spruce St, Philadelphia, PA 19104 USAShadi Asadollahi - Univ Penn, Dept Radiol, 34-00 Spruce St, Philadelphia, PA 19104 USAWilliam Y. Raynor - Univ Penn, Dept Radiol, 34-00 Spruce St, Philadelphia, PA 19104 USAAbhijit Bhattaru - Univ Penn, Dept Radiol, 34-00 Spruce St, Philadelphia, PA 19104 USAAustin J. Borja - Univ Penn, Dept Radiol, 34-00 Spruce St, Philadelphia, PA 19104 USAVincent Zhang - Univ Penn, Dept Radiol, 34-00 Spruce St, Philadelphia, PA 19104 USAThomas J. Werner - Univ Penn, Dept Radiol, 34-00 Spruce St, Philadelphia, PA 19104 USAOke Gerke - College Station Medical CenterPoul F. Hoilund-Carlsen - College Station Medical CenterAbass Alavi - Univ Penn, Dept Radiol, 34-00 Spruce St, Philadelphia, PA 19104 USA
- Publication Details
- American journal of cardiovascular disease, v 10(2), pp 101-107
- Publisher
- E-Century Publishing Corp
- Number of pages
- 7
- Grant note
- Jorgen and Gisela Thrane's Philanthropic Research Foundation, Broager, Denmark
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiology (Radiologic Sciences)
- Web of Science ID
- WOS:000548183200007
- Other Identifier
- 991019350574704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems