Journal article
Naive Human T Cells Develop into Th1 or Th0 Effectors and Exhibit Cytotoxicity Early after Stimulation with Leishmania-Infected Macrophages
The Journal of infectious diseases, v 177(5), pp 1345-1351
01 May 1998
PMID: 9593023
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Studies of human disease suggest that naturally acquired immunity is the predominant outcome of Leishmania infection. Normally protective immune mechanisms activated during asymptomatic or self-healing infections may be minimal in patients who develop disease. To explore early immune responses, an in vitro model of human Leishmania infection was developed in which naive T cells were sensitized with Leishmania-infected macrophages. An analysis of Leishmania-specific cytokine production by these T cell lines revealed that most individuals developed Th1 or Th0 responses early after infection. Infected macrophages from Th1 responders produced interleukin-12. Th0 responders who produced little or no endogenous interleukin-12 could be converted to the Th1 phenotype by addition of interleukin-12 during priming. Finally, infection-sensitized T cells specifically lysed Leishmania-infected macrophages. Thus, this in vitro model system can be used to delineate protective human immune responses against Leishmania induced early after infection.
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Details
- Title
- Naive Human T Cells Develop into Th1 or Th0 Effectors and Exhibit Cytotoxicity Early after Stimulation with Leishmania-Infected Macrophages
- Creators
- Donna M. Russo - Meharry Medical CollegePampa Chakrabarti - Meharry Medical CollegeJames M. Burns - Meharry Medical College
- Publication Details
- The Journal of infectious diseases, v 177(5), pp 1345-1351
- Publisher
- The University of Chicago Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program; Microbiology and Immunology
- Web of Science ID
- WOS:000073521100028
- Scopus ID
- 2-s2.0-0031925540
- Other Identifier
- 991020830725004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology