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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Nanoparticle Loaded Polymeric Microbubbles as Contrast Agents for Multimodal Imaging
Langmuir, v 31(43), pp 11858-11867
03 Nov 2015
PMID: 26446176
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Ultrasound contrast agents are typically microbubbles (MB) with a gas core that is stabilized by a shell made of lipids, proteins, or polymers. The high impedance mismatch between the gas core and an aqueous environment produces strong contrast in ultrasound (US). Poly(lactic acid) (PLA) MB, previously developed in our laboratory, have been shown to be highly echogenic both in vitro and in vivo. Combining US with other imaging modalities such as fluorescence, magnetic resonance imaging (MRI), or computerized tomography (CT) could improve the accuracy of many US applications and provide more comprehensive diagnostic information. Furthermore, our MB have the capacity to house a drug in the PLA shell and create drug-loaded nanoparticles in situ when passing through an ultrasound beam. To create multimodal contrast agents, we hypothesized that the polymer shell of our PLA MB platform could accommodate additional payloads. In this study, we therefore modified our current MB by encapsulating nanopartides including aqueous or organic quantum dots (QD), magnetic iron oxide nanopartides (MNP), or gold nanopartides (AuNP) to create bimodality platforms in a manner that minimally compromised the performance of each individual imaging technique.
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Details
- Title
- Nanoparticle Loaded Polymeric Microbubbles as Contrast Agents for Multimodal Imaging
- Creators
- Nutte Teraphongphom - Drexel Univ, Sch Biomed Engn Sci & Hlth Syst, Philadelphia, PA 19104 USAPeter Chhour - University of PennsylvaniaJohn R. Eisenbrey - Thomas Jefferson UniversityPratap C. Naha - University of PennsylvaniaWalter R. T. Witschey - University of PennsylvaniaBorirak Opasanont - Drexel UniversityLauren Jablonowski - Drexel UniversityDavid P. Cormode - University of PennsylvaniaMargaret A. Wheatley - Drexel University
- Publication Details
- Langmuir, v 31(43), pp 11858-11867
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 10
- Grant note
- University of Pennsylvania R00EB012165 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) SIR Foundation Allied Scientist Grant T32HL007954 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R00 EB012165; R00 HL108157 / NIH grants; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Chemical and Biological Engineering
- Web of Science ID
- WOS:000364354800014
- Scopus ID
- 2-s2.0-84946433759
- Other Identifier
- 991019168458304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary