Journal article
Nanoprobes for intracellular and single cell surface-enhanced Raman spectroscopy (SERS)
Journal of Raman spectroscopy, v 43(7), pp 817-827
01 Jul 2012
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Surface-enhanced Raman spectroscopy (SERS) is a promising and powerful label free technique for high resolution analysis of single cells. For intracellular analysis, there is a need for SERS-active nanoprobes that are minimally invasive to cells, do not affect cell viability, and provide reproducible signals. This work reviews the state-of-the-art tools currently available for intracellular SERS. Various types of SERS probes are considered, including colloidal gold and silver nanoparticles, metallized optical fibers, and tip-enhanced Raman probes. We also discuss recently developed SERS-active nanopipettes implemented on the basis of pulled glass microcapillaries. Finally, the critical aspects of selecting an optimal SERS nanoprobe for single-cell analysis depending on a particular application are summarized.
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Details
- Title
- Nanoprobes for intracellular and single cell surface-enhanced Raman spectroscopy (SERS)
- Creators
- Elina A. Vitol - Drexel UniversityZulfiya Orynbayeva - Drexel UniversityGary Friedman - Drexel UniversityYury Gogotsi - Drexel University, Materials Science and Engineering
- Publication Details
- Journal of Raman spectroscopy, v 43(7), pp 817-827
- Publisher
- Wiley
- Number of pages
- 11
- Grant note
- W. M. Keck Foundation; W.M. Keck Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Electrical and Computer Engineering; C. and J. Nyheim Plasma Institute; Materials Science and Engineering; Surgery
- Web of Science ID
- WOS:000306570400001
- Scopus ID
- 2-s2.0-84864283753
- Other Identifier
- 991019167128704721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Spectroscopy