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Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74
Journal article   Open access   Peer reviewed

Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74

Georgios Pantouris, Junming Ho, Dilip Shah, Mansoor Ali Syed, Lin Leng, Vineet Bhandari, Richard Bucala, Victor S. Batista, J. Patrick Loria and Elias J. Lolis
Angewandte Chemie (International ed.), v 57(24), pp 7116-7119
09 May 2018
DOI: https://doi.org/10.1002/anie.201803191
PMID: 29669180
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc6282165View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

allosteric site long range communications MIF Protein dynamics
Macrophage migration inhibitory factor (MIF) activates CD74, which leads to severe disorders including inflammation, autoimmune diseases and cancer under pathological conditions. Molecular dynamics (MD) simulations up to one microsecond revealed dynamical correlation between a residue located at the opening of one end of the MIF solvent channel, previously thought to be a consequence of homotrimerization, and residues in a distal region responsible for CD74 activation. Experiments verified the allosteric regulatory site and identified a pathway to this site via the MIF β-strands. The reported findings provide fundamental insights on a dynamic mechanism that controls the MIF-induced activation of CD74. Pantouris and co-workers describe an allosteric site and a dynamic mechanism by which MIF controls activation of CD74

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35 citations in Web of Science
37 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Chemistry, Multidisciplinary
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