Journal article
Nanostructured lipid carriers: effect of solid phase fraction and distribution on the release of encapsulated materials
Langmuir, v 30(46), pp 13809-13814
25 Nov 2014
PMID: 25375259
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Emulsions, solid lipid nanoparticles (SLN), and nanostructured lipid carriers (NLC) containing a mix of liquid and solid domains are of interest as encapsulation vehicles for hydrophobic compounds. Studies of the release rate from these particles yield contradictory results: Some find that increasing the fraction of solid phase increases the rate of release and others the opposite. In this paper we study the release of encapsulated materials from lipid-based nanoparticles using Monte Carlo simulations. We find that, quite surprisingly, the release rate is largely insensitive to the size of solid domains or the fraction of solid phase. However, the distribution of the domains significantly affects the rate of release: Solid domains located at the interface with the surrounding solution inhibit transport, while nanoparticles where the solid domains are concentrated in the center enhance it. The latter can lead to release rates in NLCs that are faster than in the equivalent emulsions. We conclude that controlling the release rate from NLCs requires the ability to determine the location and distribution of the solid phase, which may be achieved through choice of the surfactants stabilizing the particles, incorporation of nucleation sites, and/or the cooling rates and temperatures.
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Details
- Title
- Nanostructured lipid carriers: effect of solid phase fraction and distribution on the release of encapsulated materials
- Creators
- Nily Dan - Drexel University
- Publication Details
- Langmuir, v 30(46), pp 13809-13814
- Publisher
- American Chemical Society; Washington, DC
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000345552000011
- Scopus ID
- 2-s2.0-84912552021
- Other Identifier
- 991019312366304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary