Journal article
Natural history of claudication: Long-term serial follow-up study of 1244 claudicants
Journal of vascular surgery, v 34(6), pp 962-970
01 Dec 2001
PMID: 11743546
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: The purpose of this study was to delineate the natural history of claudication and determine risk factors for ischemic rest pain (IRP) and ischemic ulceration (IU) among patients with claudication. Methods: We prospectively collected data on 1244 men with claudication during a 15-year period, including demographics, clinical risk factors, and ankle-brachial index (ABI). We followed these patients serially with ABIs, self-reported walking distance (WalkDist), and monitoring for IRP and IU. We used Kaplan-Meier and proportional hazards modeling to find independent predictors of IRP and IU. Results: Mean follow-up was 45 months; statistically valid follow-up could be carried out for as long as 12 years. ABI declined an average of 0.014 per year. WalkDist declined at an average rate of 9.2 yards per year. The cumulative 10-year risks of development of IU and IRP were 23% and 30%, respectively. In multivariate analysis using several clinical risk factors, we found that only DM (relative risk [RR], 1.8) and ABI (RR, 2.2 for 0.1 decrease in ABI) predicted the development of IRP. Similarly, only DM (RR, 3.0) and ABI (RR, 1.9 for 0.1 decrease in ABI) were significant predictors of IU. Conclusion: This large serial study of claudication is, to our knowledge, the longest of its kind. We documented an average rate of ABI decline of 0.014 per year and a decline in WalkDist of 9.2 yards per year. Two clinical factors, ABI and DM, were found to be associated with the development of IRP and IU. Our findings may be useful in predicting the clinical course of claudication. (J Vasc Surg 2001;34:962-70.)
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Details
- Title
- Natural history of claudication: Long-term serial follow-up study of 1244 claudicants
- Creators
- Rainier AquinoChristopher JohnnidesMichel MakarounJeffrey C. WhittleVisala S. MulukMary E. KelleySatish C. Muluk
- Publication Details
- Journal of vascular surgery, v 34(6), pp 962-970
- Publisher
- Elsevier
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Cardiothoracic Surgery
- Web of Science ID
- WOS:000173002700002
- Scopus ID
- 2-s2.0-0035654172
- Other Identifier
- 991021944503604721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Peripheral Vascular Disease
- Surgery