Journal article
Natural history of multiple myeloma with de novo del(17p)
Blood cancer journal (New York), Vol.9(3), pp.32-32
07 Mar 2019
PMID: 30846679
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We compared the outcomes of 310 patients with newly diagnosed multiple myeloma with del(17p) detected by FISH to patients with high-risk translocations (HRT) (n = 79) and standard-risk (SR) cytogenetics (n = 541). The median progression-free survival (PFS) following initial therapy for the three groups was 21.1, 22, and 30.1 months, respectively (P = 0.437- del(17p) vs. HRT); the median overall survival (OS) was 47.3, 79.1, and 109.8 months, respectively, (P = 0.007- del(17p) vs. HRT). PFS and OS for patients with relative loss of 17p (n = 21) were comparable to other patients with del(17p). The PFS was similar between the del(17p) and HRT groups when stratified for age, ISS stage or treatment. The OS of del(17p) and HRT groups were similar in presence of advanced age, ISS III stage or if patients did not receive a proteasome-inhibitor containing induction. ISS III stage, high LDH and HRT, but not the percentage of cells with del(17p) predicted shorter OS in patients with del(17p). The median OS for low (ISS I, normal LDH and no HRT), intermediate (neither low nor high-risk) and high-risk (ISS III and either elevated LDH or coexistent HRT) groups among del(17p) patients were 96.2, 45.4, and 22.8 months, respectively, allowing further risk stratification.
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Details
- Title
- Natural history of multiple myeloma with de novo del(17p)
- Creators
- Arjun Lakshman - Mayo Clinic in ArizonaUtkarsh Painuly - University Hospital Hradec KrálovéS Vincent Rajkumar - Mayo Clinic in ArizonaRhett P Ketterling - Mayo Clinic in ArizonaPrashant Kapoor - Mayo Clinic in ArizonaPatricia T Greipp - Mayo Clinic in ArizonaMorie A Gertz - Mayo Clinic in ArizonaFrancis K Buadi - Mayo Clinic in ArizonaMartha Q Lacy - Mayo Clinic in ArizonaDavid Dingli - Mayo Clinic in ArizonaAngela Dispenzieri - Mayo Clinic in ArizonaAmie L Fonder - Mayo Clinic in ArizonaSuzanne R Hayman - Mayo Clinic in ArizonaMiriam A Hobbs - Mayo Clinic in ArizonaWilson I Gonsalves - Mayo Clinic in ArizonaYi Lisa Hwa - Mayo Clinic in ArizonaNelson Leung - Mayo Clinic in ArizonaRonald S Go - Mayo Clinic in ArizonaYi Lin - Mayo Clinic in ArizonaTaxiarchis V Kourelis - Mayo Clinic in ArizonaRahma Warsame - Mayo Clinic in ArizonaJohn A Lust - Mayo Clinic in ArizonaStephen J Russell - Mayo Clinic in ArizonaSteven R Zeldenrust - Mayo Clinic in ArizonaRobert A Kyle - Mayo Clinic in ArizonaShaji K Kumar - Mayo Clinic in Arizona
- Publication Details
- Blood cancer journal (New York), Vol.9(3), pp.32-32
- Grant note
- P50 CA186781 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000462347800001
- Scopus ID
- 2-s2.0-85062584929
- Other Identifier
- 991022059918004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Hematology
- Oncology