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Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Natural killer cell cytotoxicity in elderly humans after influenza immunization
Clinical and diagnostic laboratory immunology, v 3(1)
Jan 1996
PMID: 8770513
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Previous studies have reported that human natural killer (NK) cytotoxicity can be augmented by either in vitro stimulation with influenza virus antigens or in vivo administration of killed influenza vaccine. The study demonstrating the latter conclusion reported an increase in NK cytotoxicity lasting for 4 weeks postvaccination in young subjects. We initiated our study to determine if a similar increase in NK activity was observed in an elderly population after immunization with the 1992-1993 influenza vaccine. NK activity of 34 elderly (mean age, 77.3 years) was determined at 3 time points: prevaccination, 4 to 6 weeks postvaccination, and 5 to 6 months after vaccination. In contrast to the results of the previous study, the NK cytotoxicity of our elderly subjects was not augmented by the influenza vaccine at any time tested. We also determined the number of CD56+ cells in whole-blood samples at each of the time points and found that there is no change in NK cell number after influenza vaccination.
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Details
- Title
- Natural killer cell cytotoxicity in elderly humans after influenza immunization
- Creators
- J Kutza - Drexel UniversityP Gross - Drexel UniversityD Kaye - Drexel UniversityD M Murasko - Drexel University
- Publication Details
- Clinical and diagnostic laboratory immunology, v 3(1)
- Publisher
- American Society for Microbiology (ASM)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; Medicine (Graduate)
- Web of Science ID
- WOS:A1996TP77700019
- Scopus ID
- 2-s2.0-0030071804
- Other Identifier
- 991019169547104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology