Journal article
Naturally derived highly resilient and adhesive hydrogels with application as surgical adhesive
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v 253, 127192
31 Dec 2023
PMID: 37793510
Abstract
The inadequacy of conventional surgical techniques for wound closure and repair in soft and resilient tissues may lead to poor healing outcomes such as local tissue fibrosis and contracture. Therefore, the development of adhesive and resilient hydrogels that can adhere firmly to irregular and dynamic wound interfaces and provide a tension-free proximity environment for tissue regeneration has become extremely important. Herein, we describe an integrated modeling-experiment-application strategy for engineering a promising hydrogel-based bioadhesive based on recombinant human collagen (RHC) and catechol-modified hyaluronic acid (HA-Cat). Molecular modeling and simulations were used to verify and explore the hypothesis that RHC and HA-Cat can form an assembly complex through physical interactions. The complex was synergistically crosslinked via a catechol/o-quinone coupling reaction and a carbodiimide coupling reactions, resulting in superior hydrogels with strong adhesion and resilience properties. The application of this bioadhesive to tissue adhesion and wound sealing in vivo was successfully demonstrated, with an optimum collagen index, epidermal thickness, and lowest scar width. Furthermore, subcutaneous implantation demonstrated that the bioadhesive exhibited good biocompatibility and degradability. This newly developed hydrogel may be a highly promising surgical adhesive for medical applications, including wound closure and repair.
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Details
- Title
- Naturally derived highly resilient and adhesive hydrogels with application as surgical adhesive
- Publication Details
- INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v 253, 127192
- Publisher
- ELSEVIER; AMSTERDAM
- Grant note
- This work was funded by the projects of National Natural Science Foundation of China (32301209) , (82272297) , Initial Scientific Research Fund of Young Teachers in Zhengzhou University (No.32213281) , High-level Foreign Expert Introduction Plan of Henan Province (HNGD 2023001) , Guangdong Basic and Applied Basic Research Foundation (2020B1515020049) .
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:001088636800001
- Scopus ID
- 2-s2.0-85172862834
- Other Identifier
- 991021861172704721
InCites Highlights
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Applied
- Polymer Science