Files and links (1)
Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Neighborhood characteristics and leukocyte telomere length: The Multi-Ethnic Study of Atherosclerosis
Health & place, v 28, pp 167-172
01 Jul 2014
PMID: 24859373
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Telomeres are the protective caps at the ends of eukaryotic chromosomes. Telomeres get shorter each time a cell divides, and critically shortened telomeres trigger cellular senescence. Thus, telomere length is hypothesized to be a biological marker of aging. The purpose of this study was to examine the association between neighborhood characteristics and leukocyte telomere length. Using data from a subsample (n = 978) of the Multi-Ethnic Study of Atherosclerosis, a population-based study of women and men aged 45-84, we found that neighborhood social environment (but not neighborhood socioeconomic disadvantage) was associated with telomere length. Respondents who lived in neighborhoods characterized by lower aesthetic quality, safety, and social cohesion had shorter telomeres than those who lived in neighborhoods with a more salutary social environment, even after adjusting for individual-level socioeconomic status and biomedical and lifestyle factors related to telomere length. Telomere length may be one biological mechanism by which neighborhood characteristics influence an individual's risk of disease and death. (C) 2014 Elsevier Ltd. All rights reserved.
Metrics
Details
- Title
- Neighborhood characteristics and leukocyte telomere length: The Multi-Ethnic Study of Atherosclerosis
- Creators
- Belinda L. Needham - University of Michigan–Ann ArborJudith E. Carroll - University of California, Los AngelesAna V. Diez Roux - Drexel UniversityAnnette L. Fitzpatrick - University of WashingtonKari Moore - University of Michigan–Ann ArborTeresa E. Seeman - University of California, Los Angeles
- Publication Details
- Health & place, v 28, pp 167-172
- Publisher
- Elsevier
- Number of pages
- 6
- Grant note
- P30-AG028748 / UCLA Older Americans Independence Center, NIH/NIA; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) P30AG017265 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) N01-HC-95159; N01-HC-95165; N01-HC-95169; R01HL076831; R01HL101161; R01 HL071759 / NHLBI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R43HL095169 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) N01HC095169 / DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000338737300020
- Scopus ID
- 2-s2.0-84901198197
- Other Identifier
- 991019168124304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health