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Journal article
Neighborhood socioeconomic index and stroke incidence in a national cohort of blacks and whites
Neurology, v 87(22), pp 2340-2347
29 Nov 2016
PMID: 27742815
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To assess the relationship between neighborhood socioeconomic characteristics and incident stroke in a national cohort of black and white participants.
The study comprised black (n = 10,274, 41%) and white (n = 14,601) stroke-free participants, aged 45 and older, enrolled in 2003-2007 in Reasons for Geographic and Racial Differences in Stroke (REGARDS), a national population-based cohort. A neighborhood socioeconomic score (nSES) was constructed using 6 neighborhood variables. Incident stroke was defined as first occurrence of stroke over an average 7.5 (SD 3.0) years of follow-up. Proportional hazards models were used to estimate associations between nSES score and incident stroke, adjusted for demographics (age, race, sex, region), individual socioeconomic status (SES) (education, household income), and other risk factors for stroke.
After adjustment for demographics, compared to the highest nSES quartile, stroke incidence increased with each decreasing nSES quartile. The hazard ratio (95% confidence interval) ranged from 1.28 (1.05-1.56) in quartile 3 to 1.38 (1.13-1.68) in quartile 2 to 1.56 (1.26-1.92) in quartile 1 (p < 0.0001 for linear trend). After adjustment for individual SES, the trend remained marginally significant (p = 0.085). Although there was no evidence of a differential effect by race or sex, adjustment for stroke risk factors attenuated the association between nSES and stroke in both black and white participants, with greater attenuation in black participants.
Risk of incident stroke increased with decreasing nSES but the effect of nSES is attenuated through individual SES and stroke risk factors. The effect of neighborhood socioeconomic characteristics that contribute to increased stroke risk is similar in black and white participants.
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Details
- Title
- Neighborhood socioeconomic index and stroke incidence in a national cohort of blacks and whites
- Creators
- Virginia J Howard - University of Alabama at BirminghamLeslie A McClure - Drexel UniversityDawn O Kleindorfer - University of CincinnatiSolveig A Cunningham - Emory UniversityAmanda G Thrift - Florey Institute of Neuroscience and Mental HealthAna V Diez RouxGeorge Howard - Drexel University
- Publication Details
- Neurology, v 87(22), pp 2340-2347
- Grant note
- R01 AG039588 / NIA NIH HHS P60 MD002249 / NIMHD NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000392240300016
- Scopus ID
- 2-s2.0-84999836214
- Other Identifier
- 991019169620604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology