Journal article
Neodermis Formation in Full Thickness Wounds Using an Esterified Hyaluronic Acid Matrix
Journal of burn care & research, v 40(5), pp 585-589
14 Aug 2019
PMID: 30957154
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The role of the dermis is essential for the proper orchestration of all phases of the normal wound healing process. Wounds with seriously damaged or even absent dermis consistently show seriously impaired wound healing and/or long-term complications such as hypertrophic scarring. Replacing a damaged dermis requires a dermal matrix that is compatible with, or even stimulates, the process of wound healing. Hyaluronic acid (HA), in an esterified form, is among the many matrices that are available. HA has been used in a number of indications, such as ulcers (ie, diabetic foot ulcers and venous leg ulcers), trauma, including burns, and for the repair of contractures and hypertrophic scars. The shorter healing time and the decrease of recurring hypertrophy demonstrate the efficiency of HA-derived matrices. Biopsies, taken up to 12 months post-reconstruction show a neodermis that histologically is largely comparable to normal skin, which probably is a function of HA playing such a pivotal role in normal, unwounded skin, as well as in the process of healing.
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Details
- Title
- Neodermis Formation in Full Thickness Wounds Using an Esterified Hyaluronic Acid Matrix
- Creators
- Ariel Aballay - Allegheny Health NetworkMichel H. E. Hermans - President Hermans Consulting Inc, 10184 NW 52nd Terrace, Doral, FL 33178 USA
- Publication Details
- Journal of burn care & research, v 40(5), pp 585-589
- Publisher
- Oxford Univ Press
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000490466500008
- Scopus ID
- 2-s2.0-85071347405
- Other Identifier
- 991022046551504721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Critical Care Medicine
- Dermatology
- Surgery