Neonatal Genetic Variation in Steroid Metabolism and Key Respiratory Function Genes and Perinatal Outcomes in Single and Multiple Courses of Corticosteroids

K S Borowski; E A S Clark; Y Lai; R J Wapner; Y Sorokin; A M Peaceman; J D Iams; K J Leveno; M Harper; S N Caritis; M Miodovnik; B M Mercer; J M Thorp, Jr; M J O'Sullivan; S M Ramin; M W Carpenter; D J Rouse; B Sibai; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network

doi:10.1055/s-0035-1549217

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Neonatal Genetic Variation in Steroid Metabolism and Key Respiratory Function Genes and Perinatal Outcomes in Single and Multiple Courses of Corticosteroids

Journal article

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Peer reviewed

Neonatal Genetic Variation in Steroid Metabolism and Key Respiratory Function Genes and Perinatal Outcomes in Single and Multiple Courses of Corticosteroids

K S Borowski, E A S Clark, Y Lai, R J Wapner, Y Sorokin, A M Peaceman, J D Iams, K J Leveno, M Harper, S N Caritis, …

American journal of perinatology, v 32(12), pp 1126-1132

Oct 2015

DOI: https://doi.org/10.1055/s-0035-1549217

PMID: 26445141

Featured in Collection : UN Sustainable Development Goals @ Drexel

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Abstract

Adrenal Cortex Hormones - administration & dosage

Adrenal Cortex Hormones - adverse effects

Adult

Female

Genotype

Gestational Age

Humans

Infant, Newborn

Infant, Small for Gestational Age

Logistic Models

Male

Polymorphism, Single Nucleotide

Pregnancy

Premature Birth - chemically induced

Respiratory Distress Syndrome, Newborn - prevention & control

Respiratory Function Tests

The aim of the study is to evaluate the association of steroid metabolism and respiratory gene polymorphisms in neonates exposed to antenatal corticosteroids (ACS) with respiratory outcomes, small for gestational age (SGA), and response to repeat ACS. This candidate gene study is a secondary analysis of women enrolled in a randomized controlled trial of single versus weekly courses of ACS. Nineteen single nucleotide polymorphisms (SNPs) in 13 steroid metabolism and respiratory function genes were evaluated. DNA was extracted from placenta or fetal cord serum and analyzed with TaqMan genotyping. Each SNP was evaluated for association via logistic regression with respiratory distress syndrome (RDS), continuous positive airway pressure (CPAP)/ventilator use (CPV), and SGA. CRHBP, CRH, and CRHR1 minor alleles were associated with an increased risk of SGA. HSD11B1 and SCNN1B minor alleles were associated with an increased likelihood of RDS. Carriage of minor alleles in SerpinA6 was associated with an increased risk of CPV. CRH and CRHR1 minor alleles were associated with a decreased likelihood of CPV. Steroid metabolism and respiratory gene SNPs are associated with respiratory outcomes and SGA in patients exposed to ACS. Risks for respiratory outcomes are affected by minor allele carriage as well as by treatment with multiple ACS.

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6 citations in Web of Science

9 citations in Scopus

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Title: Neonatal Genetic Variation in Steroid Metabolism and Key Respiratory Function Genes and Perinatal Outcomes in Single and Multiple Courses of Corticosteroids
Creators: K S Borowski - University of Iowa
E A S Clark - University of Utah
Y Lai - George Washington University
R J Wapner - Drexel University
Y Sorokin - Wayne State University
A M Peaceman - Northwestern University
J D Iams - The Ohio State University
K J Leveno - The University of Texas at Dallas
M Harper - Wake Forest University
S N Caritis - University of Pittsburgh
M Miodovnik - Columbia University
B M Mercer - Case Western Reserve University
J M Thorp, Jr - University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
M J O'Sullivan - University of Miami*
S M Ramin - The University of Texas Health Science Center at Houston
M W Carpenter - Brown University
D J Rouse - University of Alabama at Birmingham
B Sibai - University of Tennessee Health Science Center
Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
Publication Details: American journal of perinatology, v 32(12), pp 1126-1132
Publisher: Thieme
Grant note: HD40485 / NICHD NIH HHS U10 HD027860 / NICHD NIH HHS U10 HD034122 / NICHD NIH HHS U10 HD027915 / NICHD NIH HHS HD34136 / NICHD NIH HHS HD27860 / NICHD NIH HHS UG1 HD040545 / NICHD NIH HHS U10 HD021410 / NICHD NIH HHS UG1 HD027915 / NICHD NIH HHS U10 HD040500 / NICHD NIH HHS UG1 HD034116 / NICHD NIH HHS HD21414 / NICHD NIH HHS M01-RR-000080 / NCRR NIH HHS HD40545 / NICHD NIH HHS M01 RR000080 / NCRR NIH HHS HD27869 / NICHD NIH HHS HD34208 / NICHD NIH HHS U10 HD034116 / NICHD NIH HHS HD40544 / NICHD NIH HHS HD27861 / NICHD NIH HHS UG1 HD040500 / NICHD NIH HHS K23 HD061910 / NICHD NIH HHS U10 HD036801 / NICHD NIH HHS HD27917 / NICHD NIH HHS U10 HD040545 / NICHD NIH HHS HD40560 / NICHD NIH HHS U10 HD040544 / NICHD NIH HHS U10 HD040512 / NICHD NIH HHS U10 HD034208 / NICHD NIH HHS UG1 HD040485 / NICHD NIH HHS HD36801 / NICHD NIH HHS HD40512 / NICHD NIH HHS U10 HD027869 / NICHD NIH HHS HD34116 / NICHD NIH HHS U10 HD040560 / NICHD NIH HHS U10 HD027917 / NICHD NIH HHS UG1 HD034208 / NICHD NIH HHS HD21410 / NICHD NIH HHS UG1 HD040560 / NICHD NIH HHS HD27915 / NICHD NIH HHS UG1 HD040544 / NICHD NIH HHS UG1 HD040512 / NICHD NIH HHS UG1 HD027869 / NICHD NIH HHS U10 HD027905 / NICHD NIH HHS U10 HD034136 / NICHD NIH HHS U10 HD040485 / NICHD NIH HHS HD40500 / NICHD NIH HHS U01 HD036801 / NICHD NIH HHS
Resource Type: Journal article
Language: English
Academic Unit: Design
Web of Science ID: WOS:000362699900006
Scopus ID: 2-s2.0-84943399609
Other Identifier: 991019167651504721

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Collaboration types: Domestic collaboration
Web of Science research areas: Obstetrics & Gynecology; Pediatrics

Neonatal Genetic Variation in Steroid Metabolism and Key Respiratory Function Genes and Perinatal Outcomes in Single and Multiple Courses of Corticosteroids

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Abstract

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UN Sustainable Development Goals (SDGs)

InCites Highlights

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