Journal article
Neonatal testosterone treatment increases neuron and synapse numbers in male rat superior cervical ganglion
Brain research. Developmental brain research, v 8(2)
1983
PMID: 6871720
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Abstract
Neonatal treatment with gonadal steroids has been reported to alter morphological as well as functional development in various regions of the brain and spinal cord. Among the observed alterations are changes in numbers of neurons and in the organization and numbers of synapses. These regions have been found to be sexually dimorphic, and the dimorphism dependent upon gender differences in circulating levels of gonadal steroids. Neonatal treatment with testosterone has been shown to produce an increase in the number of neurons in the superior cervical sympathetic ganglion in female rats
22. The present studies were designed to investigate the possibility of a normally occurring sexual dimorphism in the SCG of the rat, and to characterize the effect of neonatal treatment with testosterone on neurons and synapses in the male rat. We report a sexual dimorphism in the number of neurons but not in the number of preganglionic axons or ganglionic synapses. In addition, neonatal administration of testosterone propionate results in a 40% increase in the number of superior cervical ganglion neurons in treated male rats over the control male number at 15 and 30 days of age. The testosterone propionate treatment did not alter the mean nuclear diameter of these neurons. We further report that neonatal testosterone propionate treatment results in a 66% increase in the number of synapses in male superior cervical ganglia, without a concomitant increase in the number of preganglionic axons.
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Details
- Title
- Neonatal testosterone treatment increases neuron and synapse numbers in male rat superior cervical ganglion
- Creators
- Linda L. Wright - Drexel UniversityArnold J. Smolen - Drexel University
- Publication Details
- Brain research. Developmental brain research, v 8(2)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program
- Web of Science ID
- WOS:A1983QV50600001
- Scopus ID
- 2-s2.0-0020776347
- Other Identifier
- 991019184089304721
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- Web of Science research areas
- Developmental Biology
- Neurosciences