Journal article
Nerve growth factor (NGF)-treated nitrocellulose enhances and directs the regeneration of adult rat dorsal root axons through intraspinal neural tissue transplants
Neuroscience letters, v 103(1), pp 17-23
14 Aug 1989
PMID: 2779853
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Severed adult rat dorsal roots were apposed to an intraspinal transplant of fetal spinal cord (FSC) tissue co-grafted with nerve growth factor (NGF)-treated nitrocellulose strips. Axonal regrowth from the injured roots was assessed by calcitonin gene-related peptide immunoreactivity (CGRP-IR). Dense fascicles of regenerating CGRP-IR axons lined the entire length of NGF-treated nitrocellulose, with many crossing the graft host interface ventrally to extend into the host neuropil. In contrast, CGRP-IR axon regrowth was not promoted by untreated nitrocellulose implants. These results indicate that substrate bound NGF can promote and direct the intraspinal regeneration of a specific population of dorsal root axons.
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Details
- Title
- Nerve growth factor (NGF)-treated nitrocellulose enhances and directs the regeneration of adult rat dorsal root axons through intraspinal neural tissue transplants
- Creators
- John D. Houle - University of Arkansas for Medical SciencesJames E. Johnson
- Publication Details
- Neuroscience letters, v 103(1), pp 17-23
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1989AL13500004
- Scopus ID
- 2-s2.0-0024359966
- Other Identifier
- 991020545222904721
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- Web of Science research areas
- Neurosciences