Journal article
Network Controllability in the Inferior Frontal Gyrus Relates to Controlled Language Variability and Susceptibility to TMS
The Journal of neuroscience, v 38(28), pp 6399-6410
11 Jul 2018
PMID: 29884739
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In language production, humans are confronted with considerable word selection demands. Often, we must select a word from among similar, acceptable, and competing alternative words to construct a sentence that conveys an intended meaning. In recent years, the left inferior frontal gyrus (LIFG) has been identified as being critical to this ability. Despite a recent emphasis on network approaches to understanding language, how the LIFG interacts with the brain's complex networks to facilitate controlled language performance remains unknown. Here, we take a novel approach to understanding word selection as a network control process in the brain. Using an anatomical brain network derived from high-resolution diffusion spectrum imaging, we computed network controllability underlying the site of transcranial magnetic stimulation (TMS) in the LIFG between administrations of language tasks that vary in response (cognitive control) demands: open-response tasks (word generation) versus closed response tasks (number naming). We found that a statistic that quantifies the LIFG's theoretically predicted control of communication across modules in the human connectome explains TMS-induced changes in open-response language task performance only. Moreover, we found that a statistic that quantifies the LIFG's theoretically predicted control of difficult-to-reach states explains vulnerability to TMS in the closed-ended (but not open-ended) response task. These findings establish a link among network controllability, cognitive function, and TMS effects.
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Details
- Title
- Network Controllability in the Inferior Frontal Gyrus Relates to Controlled Language Variability and Susceptibility to TMS
- Creators
- John D. Medaglia - Department of Neurology.Denise Y. Harvey - Department of Neurology.Nicole White - Department of Neurology.Apoorva Kelkar - Drexel UniversityJared Zimmerman - Department of Neuroscience.Danielle S. Bassett - University of PennsylvaniaRoy H. Hamilton - Department of Neurology.
- Publication Details
- The Journal of neuroscience, v 38(28), pp 6399-6410
- Publisher
- Soc Neuroscience
- Number of pages
- 12
- Grant note
- 2-R01-DC-009209-11 / National Institutes of Health (National Institute of Mental Health); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) W911NF-10-2-0022; W911NF-14-1-0679 / Army Research Office DP5OD021352 / OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 1R01HD086888-01 / National Institutes of Health (National Institute of Child Health and Human Development); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) Perelman School of Medicine at the University of Pennsylvania (Translational Neuroscience Initiative grant) Army Research Laboratory; United States Department of Defense; US Army Research Laboratory (ARL) BCS-1441502; BCS-1430087; CAREER PHY-1554488 / National Science Foundation; National Science Foundation (NSF) T32HD071844 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) 1-DP5-OD-021352-01 / National Institutes of Health (Office of the Director); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Office of Naval Research Alfred P. Sloan Foundation John D. and Catherine T. MacArthur Foundation R01DC009209 / NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Deafness & Other Communication Disorders (NIDCD)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000438377100014
- Scopus ID
- 2-s2.0-85051059467
- Other Identifier
- 991019168535104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences