Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Neural Activity in Human Hippocampal Formation Reveals the Spatial Context of Retrieved Memories
Science (American Association for the Advancement of Science), v 342(6162), pp 1111-1114
29 Nov 2013
PMID: 24288336
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In many species, spatial navigation is supported by a network of place cells that exhibit increased firing whenever an animal is in a certain region of an environment. Does this neural representation of location form part of the spatiotemporal context into which episodic memories are encoded? We recorded medial temporal lobe neuronal activity as epilepsy patients performed a hybrid spatial and episodic memory task. We identified place-responsive cells active during virtual navigation and then asked whether the same cells activated during the subsequent recall of navigation-related memories without actual navigation. Place-responsive cell activity was reinstated during episodic memory retrieval. Neuronal firing during the retrieval of each memory was similar to the activity that represented the locations in the environment where the memory was initially encoded.
Metrics
Details
- Title
- Neural Activity in Human Hippocampal Formation Reveals the Spatial Context of Retrieved Memories
- Creators
- Jonathan F. Miller - Drexel Univ, Philadelphia, PA 19104 USAMarkus Neufang - University Medical Center FreiburgAlec Solway - Princeton UniversityArmin Brandt - University Medical Center FreiburgMichael Trippel - University Medical Center FreiburgIrina Mader - University Medical Center FreiburgStefan Hefft - University Medical Center FreiburgMax Merkow - University of PennsylvaniaSean M. Polyn - University of PennsylvaniaJoshua Jacobs - Drexel Univ, Philadelphia, PA 19104 USAMichael J. Kahana - University of PennsylvaniaAndreas Schulze-Bonhage - College Station Medical Center
- Publication Details
- Science (American Association for the Advancement of Science), v 342(6162), pp 1111-1114
- Publisher
- Amer Assoc Advancement Science
- Number of pages
- 4
- Grant note
- SFB 780-TP3 / German Research Foundation (Deutsche Forschungsgemeinschaft); German Research Foundation (DFG) R01MH055687 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) MH-061975 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Brain and Behavior Research Foundation BCNT TP B3 / Federal Ministry of Education and Research (Bundesministerium fur Bildung, Wissenschaft, Forschung und Technologie, Germany)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000327518600062
- Scopus ID
- 2-s2.0-84888794161
- Other Identifier
- 991021864299604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences